Paul Aimé Noubissi, Adela Ngwewondo, Michel Archange Fokam Tagne, Gaëtan Olivier Fankem, René Kamgang, Spasmolytic and Anti-Secretory Activities of Water/Ethanol Crinum jagus Extract, IJPPE Volume 5, International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 5)
    The present study was undertaken to determine the potential anti-secretory and spasmolytic mechanism of <i>Crinum jagus</i> water/ethanol extract (25, 50 and 100 mg/kg, po). Anti-secretory activities were evaluated using castor oil and PGE<sub>2</sub>-induced enteropooling models in rats. Spasmolytic activities were conducted on small intestinal transit, on carbachol, 5-HT-induced intestine motility as well as on naloxone-pretreated intestine transit. <i>C</i><i>.</i><i> jagus</i> extract 25, 50 and 100 mg/kg bw has significantly (p&lt;0.01) reduced in dose-dependent manner the castor oil-induced intestine secretion with inhibition rate of-59.7, -78.7 and-78.2% respectively. <i>C jagus</i> 25, 50 and 100 mg/kg bw water/ethanol extract induced significant (p&lt; 0.01) dose-dependent reduction of PGE<sub>2</sub>-induced fluid accumulation, with inhibition rate of-16.9, -57.7 and-66.2% respectively. On intestine transit, as on carbachol and on serotonin-induced intestine motility, the extract significantly (P&lt; 0.01) reduced the distance covered by the charcoal. The spasmolytic effect of <i>C jagus</i> extract was inhibited by the naloxone. These findings show that <i>C jagus</i> may reduce intestine secretion by the blockage of prostaglandins receptors. The spasmolytic effect could result from the blockage of muscarinic and/or serotonergic receptors, and by involving opiate receptors. These results support the traditional use of <i>C jagus</i> in gastrointestinal disorders treatment.
    Carbachol, <i>Crinum jagus</i> Extract, Enteropooling, Intestine Transit, Naloxone, PGE<sub>2</sub>, Rat, Serotonin