Marco Cascella, Maria Rosaria Muzio, Pharmacological Approaches and Natural Products for Prevention of Chemotherapy-Induced Peripheral Neuropathy - A Review, IJPPE Volume 6, International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 6)
    Chemotherapy-induced peripheral neuropathy (CIPN) is a one of the most common and severe cancer treatment-related adverse effect. It can often cause the stop of the treatment and affects the long-term quality of life of cancer survivors, too. Unfortunately, there are no effective agent or protocol to prevent with strong evidence of effectiveness this toxicity prevention of CIPN. Thus, CIPN prevention mainly consists of cumulative dose-reduction or lower dose-intensities, especially in higher risk patients. After a brief description of pathophysiology and features of CIPN, the purpose of this study is to analyse the role of standard pharmacological approaches and natural products for prevention of this serious side effect.
    Alternative Medicine, Cancer, Chemotherapy, Chemotherapy-Induced Peripheral Neuropathy, Polyneuropathy