Md. Abdur Rahman, Md. Saddam Hussain, Md. Shalahuddin Millat, Md. Mizanur Rahman Moghal, Evaluation of In Vitro Antimicrobial and Anti-Inflammatory Potentials of Crude Methanolic Extracts of Excoecaria agallocha (Leaves), IJPPE Volume 5, International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 5)
https://www.scipress.com/IJPPE.5.25
Abstract:
    <i>Excoecaria agallocha</i> plant (Leaves) was analyzed to explore <i>In Vitro</i> antimicrobial and membrane stabilizing activities as a crude methanolic extract. Antimicrobial activity was performed against a wide range of Gram positive(+Ve) and Gram negative(-Ve) bacteria by using disc diffusion method and various methanolic extracts of leaves of <i>E.agallocha</i> was tested for determining membrane stabilizing activity at hypotonic solution and heat induce condition and standard acetyl salicylic acid (0.10 mg/mL) was employed as standard. the zones of inhibition created was found to be 1.3 cm at a concentration of 100 µL/ disc in case of Gram negative(-Ve) bacteria Salmonella typhi. The results obtained were compared with that of a standard Ampicillin (10 µL) and imipenem (10µL), penicillin (10µl), cefoxitine(30µl). Crude methanolic extract of 10mg/ml concentration showed maximum value of 17.67±0.0102 and 18.92±0.086% respectively under hypotonic solution and heat induced condition. Thus the result suggest that, crude methanolic extracts of <i>E.agallocha</i> possessed slight to moderate antimicrobial and membrane stabilizing properties.
Keywords:
    Antimicrobial, Euphorbiaceae, <i>Excoecaria agallocha</i>, Leaves, Membrane Stabilization