Md Ashaduzzaman, Abdullah Al-Rafin, Nusrat Mustary, Sayed Md Shamsuddin, Studies on Interaction of Lidocaine Drug with Natural Cellulosic Fibres, IJPPE Volume 4, International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 4)
https://www.scipress.com/IJPPE.4.36
Abstract:
    Naturally engineered cellulosic fibres are of particular interest due to their diverse interfacial behavior; which could be well suited to operating interaction with functionalized drug. In the present work, interaction of Lidocaine (LC) hydrochloride, 2-(diethylamino)-<i>N</i>-(2,6-dimethylphenyl) acetamide was widely studied with cellulosic fibres i.e. cotton, jute and coir in presence of 0.1M HCl aqueous solution. In UV-Vis spectroscopy measurement, it is revealed that the highest interaction (adsorption 18 mg/g of fibres) of LC was occurred onto the cotton fibres surfaces from 3.5 mg/mL aqueous solution after 30 minutes gentle shaking. Kinetic studies in case of cotton fibres showed a linear relationship (R<sup>2</sup> = 0.9987) during desorption of LC upto 30 minutes at 25 °C temperature. The cotton fibres concentration was to be calculated 0.0085 g unit mol/L by considering the unit molecular weight of glucose unit. When 2.5 mg/mL (0.0108 g mol/L) LC drug solution was used then the ratio between glucose unit and LC drug was found to be 1.27. The interaction of LC was also increased direct-proportionally to the weight of cotton fibres. The resulting interaction phenomena of model LC would help us to deign dosage of anesthetic drug for specific physiological conditions.
Keywords:
    Absorption Spectroscopy, Adsorption, Desorption, Drug Interaction, Self-Assembly