Caterina Soldà, Romeo Bardini, Francesca Zingales, Davide Pastorelli, A Case of Locally Advanced Pancreatic Cancer Successfully Resected after 14 Months Therapy with Gemcitabine and Meriva®, IJPPE Volume 2, International Journal of Pharmacology, Phytochemistry and Ethnomedicine (Volume 2)
https://www.scipress.com/IJPPE.2.1
Abstract:
    Pancreatic cancer (PC) is one of the leading cause of cancer death. Neoadjuvant therapy has been progressively used in the context of locally advanced/unresectable disease improve patients’ outcome. New drugs combination are associated with increased response rate but at the expense of higher toxicities. We presented a case of a patient with locally advanced disease treated who could undergo surgery after 14 cycles of therapy with gemcitabine and curcumin conjugated with phospholipids (Meriva<sup>®</sup>). Treatment was well tolerated without severe toxicities or impairment of quality of life. The patient is disease free at 9 month from surgery and 28 months from initial diagnosis and he still is in good clinical conditions. The combination of gemcitabine and Meriva® was effective in allowing radical surgery in a patient with locally advanced PC. Moreover, this results was obtained with minimally toxic regimen.
Keywords:
    Curcumin, Gemcitabine, Locally Advanced, Neoadjuvant, Pancreatic Cancer