Kadiri Oseni, Respiratory Surveillance and Ca2+-ATPase Enzyme Activity Studies of Clarias gariepinus Exposed to Acute Toxicity of Cyanide, ILNS Volume 50, International Letters of Natural Sciences (Volume 50)
    Potassium cyanide, a highly contaminating and toxic aquatic ecosystems pollutant was investigated for acute toxicity on the freshwater fish <i>Clarias</i> <i>gariepinus</i><i>. </i>Its effect on the Ca<sup>2+</sup> -ATPase activities in the liver, gills, muscle and intestinal tissues and oxygen consumption index was studied. Short-term toxicity test was carried out by static renewal bioassay test over a 96 h period using a lethal concentration (LC<sub>50</sub>) value of 0.361mg/mL. Potassium cyanide was highly toxic to the animal tested. Results reveal that normal respiratory activity (O<sub>2 </sub>consumption) of the fish was significantly affected and there was significant decreased in the Ca<sup>2+</sup> - ATPase activities at the end of exposure periods (24, 48, 72 and 96 h). Correlation analysis reveals a strong relationship between oxygen consumption index and ATPase enzyme activity of <i>Clarias</i> <i>gariepinus</i> exposed to the toxicant. This study reflects the toxic effect of potassium cyanide to the freshwater fish, <i>Clarias</i> <i>gariepinus</i> and suggestion on the possible application of Ca<sup>2+</sup> -ATPase activities and oxygen consumption index as possible biomarkers for early detection of cyanide poisoning in aquatic bodies.<sub></sub>
    Ca<sup>2+</sup>-ATPase, Catfish, Cyanide, LC<sub>50</sub>, Toxicity