Thiyagarajan Rajeshwari, Boobalan Raja, Antioxidant and Free Radical Scavenging Effect of D-Carvone in Hypertensive Rats In Vivo and In Vitro Study, ILNS Volume 35, International Letters of Natural Sciences (Volume 35)
https://www.scipress.com/ILNS.35.6
Abstract:
    This study was planned to assess the antioxidant and free radical scavenging effect of D-carvone against L-NAME (N<sup>ω</sup>-nitro-L-arginine methyl ester hydrochloride) induced hypertension. Hypertension was encouraged in adult male albino rats of the Wistar strain, considering 180–230 g, by oral administration of the L-NAME (40 mg/kg/ body weight/day) in drinking water for 4 weeks. Rats were cured with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. A significant reduction in the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH), in plasma were perceived in L-NAME induced hypertensive rats. Moreover, <i>in vitro</i> free radical scavenging activity of ABTS<sup>+</sup> and DPPH<sup>•</sup> radical scavenging possible of D-carvone was also quantified. Treatment with D-carvone (5, 10 and 20 mg/kg bw) carries back all the above parameters to near usual level, in which 20 mg/kg displayed the highest effect than that of other two doses. Further, D-carvone displays concentration dependent antioxidant potential. These results suggest that D-carvone acts as an antioxidant and free radical scavenging agent against L-NAME induced hypertension.
Keywords:
    Antioxidant, D-Carvone, Free Radicals, Hypertension