Thiyagarajan Rajeshwari, Boobalan Raja, Antioxidant and Free Radical Scavenging Effect of D-Carvone in Hypertensive Rats In Vivo and In Vitro Study, ILNS Volume 35, International Letters of Natural Sciences (Volume 35)
    This study was planned to assess the antioxidant and free radical scavenging effect of D-carvone against L-NAME (N<sup>ω</sup>-nitro-L-arginine methyl ester hydrochloride) induced hypertension. Hypertension was encouraged in adult male albino rats of the Wistar strain, considering 180–230 g, by oral administration of the L-NAME (40 mg/kg/ body weight/day) in drinking water for 4 weeks. Rats were cured with D-carvone (5, 10 and 20 mg/kg body weight) for four weeks. A significant reduction in the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and reduced glutathione (GSH), in plasma were perceived in L-NAME induced hypertensive rats. Moreover, <i>in vitro</i> free radical scavenging activity of ABTS<sup>+</sup> and DPPH<sup>•</sup> radical scavenging possible of D-carvone was also quantified. Treatment with D-carvone (5, 10 and 20 mg/kg bw) carries back all the above parameters to near usual level, in which 20 mg/kg displayed the highest effect than that of other two doses. Further, D-carvone displays concentration dependent antioxidant potential. These results suggest that D-carvone acts as an antioxidant and free radical scavenging agent against L-NAME induced hypertension.
    Antioxidant, D-Carvone, Free Radicals, Hypertension