M.N. Islam, S.M.S. Shahriar, M.K. Islam, M. Jesmin, M.M. Ali, J.A. Khanam, Antibacterial Activities of Some Transition Metal Schiff Base Complexes, Volume 10, International Letters of Chemistry, Physics and Astronomy (Volume 10)
https://www.scipress.com/ILCPA.10.12
Abstract:
    A new series of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylidene glycinato diaqua cobalt (II) dimer] (SGCo)<sub>2</sub>, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)<sub>2</sub>, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylidene glycinato diaqua zinc(II) dimer] (SGZ)<sub>2</sub> have been synthesized and characterized through a rapid, simple, and efficient methodology in excellent yield. These compounds were screened for<i> In Vitro</i> antibacterial activities against six pathogenic bacteria, such as <i>Shigella sonnei</i>, <i>Escherichia coli</i>, <i>Bacilus subtilis</i>, <i>Sarcina lutea</i>,<i> Staphylococcus aureus</i> and <i>Pseudomonas arioginosa</i>. The antibacterial activity was determined by the disc diffusion method using DMSO as solvent. The results indicate that (SGC) compound exhibit a significant antibacterial activity, depending on the bacterial strain and (SGCo)<sub>2</sub>, (SGN)<sub>2</sub> and (SGZ)<sub>2</sub> compounds show a moderate sensitivity even with higher doses. All these compounds were found to possess cytotoxic effect.
Keywords:
    Antibacterial Activity, Brine Shrimp Lethality, Minimum Inhibitory Concentration, Schiff Base Transition Metal Complexes