A. Raguraman, N. Santhi, Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity, Volume 39, International Letters of Chemistry, Physics and Astronomy (Volume 39)
https://www.scipress.com/ILCPA.39.219
Abstract:
    A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P<sub>1</sub>-P<sub>10</sub>) have been synthesized by the reaction of substituted chalcones (C<sub>1</sub>-C<sub>10</sub>) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, <sup>1</sup>HNMR and <sup>13</sup>C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.
Keywords:
    2-Pyrazoline, 4-Methylacetophenone, Antibacterial, Antifungal, Chalcone, Ultrasonic Irradiation