Nayan H. Bhuva, Vrajlal K. Gothalia, Pankaj M. Singala, Pratik K. Talpara, Viral J. Faldu, Viresh H. Shah, Synthesis of Novel 2-Mercapto-4-(p-Aminophenyl Sulphonylamino)-6-(Aryl)-Pyrimidine-5-Carboxamide Derivatives via the Biginelli Reaction, ILCPA Volume 36, International Letters of Chemistry, Physics and Astronomy (Volume 36)
https://www.scipress.com/ILCPA.36.168
Abstract:
    Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h.. The newly synthesized compounds were characterized by elemental analyses, infrared (IR), 1H NMR and 13C NMR spectroscopic investigation.
Keywords:
    2-Mercapto-4-(p-Aminophenyl Sulphonylamino)-6-(Aryl)-Pyrimidine-5-Carboxamide, Biginelli Condensation