N. Kalyanasundaram, S.P. Sakthinathan, R. Suresh, D. Kamalakkannan, S. John Joseph, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan, Spectral Correlation Analysis of Hammett Substituent Constants and Biological Activities of some (E)-1-(4-Phenoxyphenyl)-3-Phenylprop-2-en-1-Ones, ILCPA Volume 28, International Letters of Chemistry, Physics and Astronomy (Volume 28)
    A series of aryl chalcones have been synthesized from 4-phenoxyacetophonone with various substituted benzaldehydes. The purity of all chalcones has been checked using their physical constants and spectral data. These spectral data have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effect of substituents on the above spectral data has been studied. The single parameter correlation with few Hammett constants and F and R parameters gave satisfactory correlation coefficients whereas all multiple correlations gave satisfactory correlation coefficients with Resonance, Field and Swain-Lupton’s parameters. The antimicrobial activities of all chalcones have been studied using Bauer-Kirby method.
    Antimicrobial Activities, Hammett Constants, IR Spectra, NMR Spectra, Regression Analysis, Substituent Effects, Substituted Styryl 4-Phenoxyphenylketones, UV Spectra