M. Rajarajan, R. Vijayakumar, R. Senbagam, S. Balaji, V. Manikandan, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan, Synthesis, Hammett Spectral Correlations and Antimicrobial Activities of (E)-1-Benzylidene-2-(4-Chlorophenyl)Hydrazines, Volume 59, International Letters of Chemistry, Physics and Astronomy (Volume 59)
    In the present study, a series of nine number of (<i>E</i>)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been synthesized by condensation reaction of meta and para substituted benzaldehydes with 4-chlorophenylhydrazine using acetic acid catalyst. They are characterized by their physical constants, UV (200-450 nm), Infra-Red (KBr, 4000-400 cm<sup>−1</sup>) and NMR (<sup>1</sup>H and <sup>13</sup>C) spectral data. The observed UV, IR and NMR spectral data have been correlated with Hammett substituent constants and Swain-Lupton’s <i>F</i> and <i>R</i> parameters using single and multi-linear regression analysis. From the results of statistical analysis the effects of substituents on the spectral data have been discussed. The antimicrobial activities of all the synthesized (<i>E</i>)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been studied using Bauer–Kirby method.
    4-Chlorophenylhydrazine, 4-Chlorophenylhydrazone, Acetic Acid, Antimicrobial Activities, Hydrazones, Spectral Correlation, Synthesis