S. Balaji, M. Rajarajan, R. Vijayakumar, V. Manikandan, R. Senbagam, Ganesan Vanangamudi, G. Thirunarayanan, Synthesis and Assessment of Substituent Effect on (E)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds, ILCPA Volume 57, International Letters of Chemistry, Physics and Astronomy (Volume 57)
https://www.scipress.com/ILCPA.57.145
Abstract:
    In the present investigation, a series of substituted (<i>E</i>)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds were synthesized by condensation reaction of 4-fluoro-3-methyl acetophenone with substituted benzaldehydes in the presence of alkali. The yields of synthesized compounds are more than 80%. The structures of all the synthesized compounds were confirmed by their physical constants, UV, IR and NMR spectral data. All the observed spectral data of substituted (<i>E</i>)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds have been correlated with Hammett substituent constants and <i>F</i> and <i>R</i> parameters using single and multi-linear regression analyses. From the results of statistical analysis the effects of substituents have been discussed.
Keywords:
    4-Fluoro-3-Methyl Acetophenone, IR, NMR Spectra, Spectral Correlation Analysis, Substituent Effect, Synthesis, UV