R. Arulkumaran, S. Vijayakumar, R. Sundararajan, S.P. Sakthinathan, D. Kamalakkannan, R. Suresh, K. Ranganathan, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan, Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones, Volume 4, International Letters of Chemistry, Physics and Astronomy (Volume 4)
https://www.scipress.com/ILCPA.4.17
Abstract:
    A series of substituted styryl 3,5-dichloro-2-hydroxyphenyl ketones [1-(3,5-dichloro-2-hydroxy)-3-phenylprop-2-en-1-one] were synthesized using thionyl chloride assisted Crossed-Aldol reaction. The yields of chalcones were more than 80%. The synthesized chalcones were characterized by analytical and spectroscopic data. From the spectroscopic data the group frequencies were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis the effect of substituents were discussed. The antibacterial activities of these chalcones have been evaluated using Bauer-Kirby method.
Keywords:
    Antimicrobial Activities, Hammett Correlation, IR Spectra, NMR Spectra, Styryl 3,5-Dichloro-2-Hydroxyphenyl Ketones, Substituent Effects, Thionylchloride