Shipra Baluja, Rahul Bhalodia, Mehul Bhatt, Nayan Vekariya, Ravi Gajera, Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures, ILCPA Volume 17, International Letters of Chemistry, Physics and Astronomy (Volume 17)
    The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb’s energy (<i>ΔG</i><sub><i>so</i>l</sub>), heat of solution (<i>ΔH<sub>sol</sub></i>) and entropy of solution (<i>ΔS<sub>sol</sub></i>) have also been evaluated.
    Isatin, Solubility, Thermodynamic Parameters