Shipra Baluja, Rahul Bhalodia, Mehul Bhatt, Nayan Vekariya, Ravi Gajera, Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures, Volume 17, International Letters of Chemistry, Physics and Astronomy (Volume 17)
https://www.scipress.com/ILCPA.17.36
Abstract:
    The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb’s energy (<i>ΔG</i><sub><i>so</i>l</sub>), heat of solution (<i>ΔH<sub>sol</sub></i>) and entropy of solution (<i>ΔS<sub>sol</sub></i>) have also been evaluated.
Keywords:
    Isatin, Solubility, Thermodynamic Parameters