M. Emayavaramban, N. Santhi, C. Gopi, C. Manivannan, A. Raguraman, Synthesis, Characterization and Anti-Diabetic Activity of 1,3,5-Triaryl-2-Pyrazolines in Acetic Acid Solution under Ultrasound Irradiation, Volume 14, International Letters of Chemistry, Physics and Astronomy (Volume 14)
https://www.scipress.com/ILCPA.14.172
Abstract:
    A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide/semicarbazide hydrochloride/benzhydrazide/benzenesulphonyl hydrazide/phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, <sup>1</sup>H-NMR, <sup>13</sup>CNMR spectral data. All the target compounds were evaluated for their <i>In Vivo</i> anti-diabetic activity in rates in comparison with as reference drug.
Keywords:
    Alloxan Monohydrate, Anti-Diabtic Activity, Chalcone, Pyrazoline, Ultrasound Irradiation