Mayur K. Vekariya, Rajesh H. Vekariya, Nirav N. Barot, Tauhid A. Shaikh, Harjinder Kaur, Nisha K. Shah, One Pot, Solvent-Free Synthesis of Substituted 3,4-Dihydropyrimidin-2(1H)-Ones/Thiones under Microwave Irradiation (CEM) Using Reusable Nickel Nanoparticles, ILCPA Volume 50, International Letters of Chemistry, Physics and Astronomy (Volume 50)
https://www.scipress.com/ILCPA.50.17
Abstract:
    A library of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives were synthesized via Biginelli condensation reaction of β-keto esters, aryl aldehydes and urea/thiourea under solvent-free conditions utilizing nickel nanoparticles under microwave irradiation (CEM Discover). The structures of the all compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and Mass spectral data. Nickel nanoparticles can be recovered and reused five times without loss of their efficiency. Short reaction time, high yield of products and simple workup procedure, solvent-free conditions and reusability of the catalyst are the superior features of this protocol.
Keywords:
    3,4-Dihydropyrimidin-2(1H)-Ones/Thiones Derivatives, Biginelli Condensation, Microwave Irradiation, Nickel Nanoparticles, Solvent-Free