G. Thirunarayanan, V. Sathiyendiran, Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles, ILCPA Volume 49, International Letters of Chemistry, Physics and Astronomy (Volume 49)
https://www.scipress.com/ILCPA.49.1
Abstract:
    Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H<sub>2</sub>SO<sub>4</sub> catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radical scavenging and castor-leaf disc bioassay of 4<sup>th</sup> instar larvae <i>Achoea Janata L</i> methods.
Keywords:
    Antimicrobial Activity, Antioxidant Activity, Dihydroisoxazole, Environmentally Benign Reaction, Insect Antifeedant Activity, NMR Spectra