Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILNS > Volume 53 > Mini-Review on the Glucose Metabolism...
< Back to Volume

Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection

Full Text PDF

Abstract:

Pancreatic cancer is one of the most severe malignant disease, with an extreme degree of lethality, considering that the survival rate at 5 years is up to 4%. In addition, a major disadvantage of this disease is the fact that the diagnosis is determined very late in the evolution of the disorder, despite the development of new technologies. In this way, the main symptoms are occurring later on, when the tumour is already locally advanced and unresectable. Up to now surgery is the only modality that can provide a greater chance of survival, but unfortunately the pancreatic resection has many unknowns and controversies around it. Moreover, the studies on endocrine pancreatic function after resection are very few and somehow controversial. In this way, in the present mini-review we will describe the most relevant experimental data regarding the post-resection pancreatogenic diabetes, the pancreatic polypeptide PP and the pancreatic glucose metabolism after resection or the glucose metabolism after partial or total pancreatectomy.

Info:

Periodical:
International Letters of Natural Sciences (Volume 53)
Pages:
65-71
Citation:
D. Timofte et al., "Mini-Review on the Glucose Metabolism Modifications after Pancreatic Resection", International Letters of Natural Sciences, Vol. 53, pp. 65-71, 2016
Online since:
April 2016
Export:
Distribution:
References:

[1] V. Surlin, V. Bintintan, F. Petrariu, R. Dobrin, R. Lefter, A. Ciobică, D. Timofte, Prognostic factors in resectable pancreatic cancer, Rev Med Chir Soc Med Nat Iasi. 118 (2014) 924-31.

[2] D. Timofte, R. Danila, A. Ciobica, C. Diaconu, R. Livadaru, L. Ionescu, The relevance of some tumoral markers in patients with pancreatic cancer, Analele Stiintifice ale Universitatii" Al. I. Cuza" Din Iasi. 15 (2014) 51-58.

[3] C. Morrow, Chronic pancreatitis: long-term surgical results of pancreatic duct drainage, pancreatic resection, and near-total pancreatectomy and islet autotransplantation, Surgery. 96 (1984) 608-16.

[4] H. Beger, M. Buchler, Duodenum-preserving resection of the head of the pancreas in chronic pancreatitis with inflammatory mass in the head, World J Surg. 14 (1990) 83-7.

DOI: https://doi.org/10.1007/bf01670550

[5] L. Traverso, R.A. Kozarek, Pancreatoduodenectomy for chronic pancreatitis: anatomic selection criteria and subsequent long-term outcome analysis, Ann Surg. 226 (1997) 429-35.

DOI: https://doi.org/10.1097/00000658-199710000-00004

[6] R. Schwarz, D. Smith, Extent of lymph node retrieval and pancreatic cancer survival: information from a large US population database, Ann Surg Oncol. 13 (2006) 1189–1200.

DOI: https://doi.org/10.1245/s10434-006-9016-x

[7] A. Andren-Sandberg I. Ihse, Factors influencing survival after total pancreatectomy in patients with pancreatic cancer, Ann Surg. 198 (1983) 605-10.

DOI: https://doi.org/10.1097/00000658-198311000-00008

[8] D. Krusch, T. Pruett, G. Cornett, J. Hanks, Surgical alterations of the pancreas and insulin-independent glucose disposal, J Surg Res. 52 (1992) 476-82.

DOI: https://doi.org/10.1016/0022-4804(92)90315-q

[9] R. Nosadini, Insulin sensitivity, binding, and kinetics in pancreatogenic and type I diabetes. Diabetes. 31 (1982) 346-55.

[10] H. Karmann, F. Laurent, P. Mialhe, Pancreatic hormones disappearance after total pancreatectomy in the duck: correlation between plasma glucagon and glucose. Horm Metab Res. 19 (1987) 538-41.

DOI: https://doi.org/10.1055/s-2007-1011877

[11] R. Unger, Glucagon physiology and pathophysiology, N Engl J Med. 285 (1971) 443-9.

[12] S. Kreutzenberg, Glucose turnover and recycling in diabetes secondary to total pancreatectomy: effect of glucagon infusion, J Clin Endocrinol Metab. 70 (1990) 1023-9.

DOI: https://doi.org/10.1210/jcem-70-4-1023

[13] L. Slezak, D. Andersen, Pancreatic resection: effects on glucose metabolism, World J Surg. 25 (2001) 452-60.

[14] A. Fowden, W. Hay, The effects of pancreatectomy on the rates of glucose utilization, oxidation and production in the sheep fetus, Q J Exp Physiol. 73(1988) 973-84.

DOI: https://doi.org/10.1113/expphysiol.1988.sp003231

[15] C. Frey C. Child, W. Fry, Pancreatectomy for chronic pancreatitis, Ann Surg. 184 (1976) 403-13.

[16] N. Seymour, Alterations in hepatocyte insulin binding in chronic pancreatitis: effects of pancreatic polypeptide, Am J Surg. 169 (1995) 105-9.

[17] D. Andersen, C Ruiz, C Burant, Insulin regulation of hepatic glucose transporter protein is impaired in chronic pancreatitis, Ann Surg. 219 (1994) 679-86.

DOI: https://doi.org/10.1097/00000658-199406000-00011

[18] A. Ciobica, V. Bild, L. Hritcu, M. Padurariu, W. Bild, Effects of angiotensin II receptor antagonists on anxiety and some oxidative stress markers in rat, Central European Journal of Medicine. 6 (2011) 331-340.

DOI: https://doi.org/10.2478/s11536-011-0010-8

[19] W Bild, A Ciobica, Angiotensin-(1–7) central administration induces anxiolytic-like effects in elevated plus maze and decreased oxidative stress in the amygdala, Journal of affective disorders. 145 (2013) 165-171.

DOI: https://doi.org/10.1016/j.jad.2012.07.024

[20] W. Bild, L. Hritcu, C. Stefanescu, A. Ciobica, Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus, Progress in Neuro-Psychopharmacology and Biological Psychiatry. 43 (2013) 79-88.

DOI: https://doi.org/10.1016/j.pnpbp.2012.12.009

[21] N. Seymour, Reversal of abnormal glucose production after pancreatic resection by pancreatic polypeptide administration in man, Surgery. 104 (1988) 119-29.

[22] M. Buchler, Randomized trial of duodenum-preserving pancreatic head resection versus pylorus-preserving Whipple in chronic pancreatitis, Am J Surg. 169 (1995) 65-9.

DOI: https://doi.org/10.1016/s0002-9610(99)80111-1

[23] G. Aspelund, Improved outcomes for benign disease with limited pancreatic head resection, J Gastrointest Surg. 9 (2005) 400-9.

[24] H. Ho, C Frey, The Frey procedure: local resection of pancreatic head combined with lateral pancreaticojejunostomy, Arch Surg. 136 (2001) 1353-8.

DOI: https://doi.org/10.1001/archsurg.136.12.1353

[25] H. Dammann, Gut-hormone profile in totally pancreatectomised patients, Gut. 22(1981) 103-7.

DOI: https://doi.org/10.1136/gut.22.2.103

[26] G. Boden, Glucagon deficiency and hyperaminoacidemia after total pancreatectomy, J Clin Invest. 65 (1980) 706-16.

DOI: https://doi.org/10.1172/jci109717
Show More Hide
Cited By:

[1] D. Timofte, L. Ionescu, L. Ochiuz, "An Evaluation of the Relative Distribution of Romanian Patients with Pancreatic Neoplasm", International Journal of Pharmacology, Phytochemistry and Ethnomedicine, Vol. 4, p. 83, 2016

DOI: https://doi.org/10.18052/www.scipress.com/IJPPE.4.83