Acute Toxicity and Dose Fixation Studies on Chloroxylon swietenia Dc Bark Extracts on Streptozotocin Induced Diabetic Rats

Jayaprasad, B.; Sharavanan, P.S.; Sivaraj, R.

doi:10.18052/www.scipress.com/ILNS.48.8

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Acute Toxicity and Dose Fixation Studies on Chloroxylon swietenia Dc Bark Extracts on Streptozotocin Induced Diabetic Rats

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Abstract:

Diabetes mellitus (DM) is a chronic metabolic disease with the highest rates of prevalence and mortality worldwide. Chloroxylon swietenia has been used extensively in folkloric medicine. The present study aims to determine the acute toxicity of Chloroxylon swietenia bark methanol (CSBMEt) and aqueous extracts (CSBAEt) (100, 150, 250, 500 and 1000 mg/kg body weight) and dose fixation of CSBMEt and CSBAEt in streptozotocin induced diabetic rats. Diabetes was induced in male albino wistar rats by single intraperitoneal injection of streptozotocin (50mg/kg b.w). The diabetic rats were administered with Chloroxylon swietenia bark extracts (CSBMEt and CSBAEt) (75,125 and 250mg/kg b.w) orally by intragastric intubation for 15 days. Acute toxicity studies revealed the non-toxic nature of the CSBMEt and CSBAEt. No lethality or toxic reactions found at any doses until the end of study, whereas 75 and 125 mg/kg b.w. doses of CSBMEt and CSBAEt produce no significant changes in the diabetic rats and 250mg/kg b.w. of CSBMEt and CSBAEt have significant change in the blood glucose. The results conclude that, there was no toxicity observed up to 1000mg/kg b.w. of both the extracts and 250mg/kg b.w. of CSBMEt and CSBAEt can be used as effective dose to treat diabetes.

Info:

Periodical:

International Letters of Natural Sciences (Volume 48)

Pages:

8-13

DOI:

https://doi.org/10.18052/www.scipress.com/ILNS.48.8

Citation:

B. Jayaprasad et al., "Acute Toxicity and Dose Fixation Studies on Chloroxylon swietenia Dc Bark Extracts on Streptozotocin Induced Diabetic Rats", International Letters of Natural Sciences, Vol. 48, pp. 8-13, 2015

Online since:

November 2015

Authors:

B. Jayaprasad, P.S. Sharavanan, R. Sivaraj

Keywords:

Acute Toxicity, Antidiabetic, Chloroxylon swietenia, Dose Fixation

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Open Access

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Creative Commons Attribution 4.0 International License

References:

[1] Bastaki. S, Diabetes mellitus and its treatment. International Journal of Diabetes and Metabolism, 1995; 13; 111–134.

[2] Adeghate. E, Schatter. P, Dunn. E. An update on the etiology and epidemiology of diabetes mellitus. Ann NY Acad Sci, 2006: 1084: 1-29.

[3] Wild. S, Roglie. G, Green. A, King. H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care, 2004; 27: 1047-105.

DOI: https://doi.org/10.2337/diacare.27.5.1047

[4] Wu. C, Li. Y, Chen . Y et al., Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction, Phytomedicine, 2011; 18(4): 292–297.

DOI: https://doi.org/10.1016/j.phymed.2010.07.005

[5] Tiwari. AK, Madhusudana. RJ. Diabetes mellitus and multiple therapeutic approaches of phytochemicals: present status and future prospects. Current Science, 2002; 83: 30-8.

[6] American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care, 2005: 28: 37–42.

[7] Venkateshwarlu. E, Sharvanabhava. BS, Arvind. P, Rakeshkumar. Reddy. P, Dileep. P, Mahathi. K. Evaluation of anti‑diabetic and hypolipidemic activity of Pseudarthria viscida (whole plant) in streptozotocin‑nicotinamide induced Type II diabetic rats. Glob J Pharmacol 2013; 7: 192‑7.

[8] Hansotia. T, Drucker. DJ. GIP and GLP-1 as incretin hormones: lessons from single and double incretin receptor knockout mice. Regulatory Peptides 2005; 128: 125–134.

DOI: https://doi.org/10.1016/j.regpep.2004.07.019

[9] Liu. JP, Zhang, M, Wang, WY, Grimsgaard, S. Chinese herbal medicines for type-2 diabetes mellitus. Cochrane Database of Systematic Reviews, 2004; 3: 3642.

DOI: https://doi.org/10.1002/14651858.cd003642

[10] Cragg. GM, Newman. DJ. Natural product drug discovery in the next millennium. Pharm. Biol, 2001; 39(1): 8-17.

[11] Patchimatla. A, Kankanala. SR, Bandaru. SS, Kulindaivelu. U, Jupally. VR, Eggadi. V. Investigation of lipid profile and ocular oxidative stress of Chloroxylon swietenia on Streptozotocin-nicotinamide induced diabetic rats. Int J Green Pharm 2014; 8: 90-6.

DOI: https://doi.org/10.4103/0973-8258.129577

[12] Jayaprasad. B, Sharavanan. PS, Karthik K. Chloroxylon swietenia an IUCN red listed plant – medicinal uses. Int J Res Eng Biosci, 2014; 2: 213–217.

[13] Ghosh, MN. Toxicity studies. In: Fundamentals of Experimental Pharmacology. Scientific Book Agency, Calcutta, 1984; 153–158.

[14] Turner. MA. 1965. Screening Methods in Pharmacology. Academic Press, New York, p.26.

[15] Gupta. R, Gupta. RS. Hypolipidemic activity of Pterocarpus marsupium in streptozotocin induced diabetes. J Complementary Integrative Med. 2009; 6: 1–28.

[16] Kumar. V, Yadav. PKS, Singh. UP, Bhat. HR, Zaman. K, Ali. MD: Isolation of new racemic sugar (D/L galacturonic acid) from leaves of Paederia foetida Linn. Nature Proc 2011. doi: 10. 1038/npre. 2011. 5752. 1.

DOI: https://doi.org/10.1038/npre.2011.5752.1

[17] Dewick, PM. 1996. Tumor inhibition from plants: Tease and Evans.

[18] Prosper-Cabral. N. Biapa, Gabriel A. Agbor, Julius E. Oben, Jeanne Y. Ngogang. Phytochemical studies and antioxidant properties of four medicinal plants used in Cameroon. Afr. J. Trad. Cam. 2007: 4(4); 495 – 500.

DOI: https://doi.org/10.4314/ajtcam.v4i4.31243

[19] Harborne. JB, Phytochemicals methods, A guide to modern techniques of plant analysis, Chapman and hall London (1973).

[21] Venkatesh. S, Reddy. GD, Reddy. BM, Ramesh. M, Apparao. AVN. Fitoterapia, 2003, 74, 274-279.

[22] Rajalakshmi. M, Eliza. J, Priya. CE, Nirmala. A, Daisy. P. Afr.J. Pharm. Pharmacol., 2009, 3, 5, 171-180.

[23] Patwardhan. B, Vaidya. ADB, Chorghade M, 2004. Ayurveda and natural products drug discovery. Current sciences, 86(6): 789-799.

[24] Jayaprasad. B, Sharavanan. PS. Phytochemical, In Vitro Antioxidant and Antimicrobial Activities in Aqueous and Methanol Extracts Of Chloroxylon Swietenia Bark. RJPBCS 2015: 6(1); 1416-1424.

[25] Asante-Duah, K. Public Health Risk Assessment for Human Exposure to Chemicals (illustrated. ); Kluwer Academic Publishers: Dordrecht, The Netherlands, 2002; Volume 6.

[26] Moshi, MJ. Brine shrimp toxicity evaluation of some Tanzanian plants used traditionally for the treatment of fungal infections. Afr. J. Tradit. Complement. Altern. Med. 2007, 4, 219-225.

DOI: https://doi.org/10.4314/ajtcam.v4i2.31211

[27] Mahadeva Rao US, Bizuneh Adinew. Remnant β-cell-stimulative and anti-oxidative effects of persea americana fruit extract studied in rats introduced into streptozotocin - induced hyperglycaemic state. Afr J Tradit Complement Altern Med. (2011).

DOI: https://doi.org/10.4314/ajtcam.v8i3.65277

[28] Gurudeeban. S, Satyavani. K, Sengottuvel. S, Thamotharan. G, Ramanathan. T. Antidiabetic and Antihyperlipidemic Effects of Rhizophora apiculata Blume Extracts. The Pharma Innovation Journal 2015; 4(6): 31-35.

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Cited By:

[1] B. Jayaprasad, P. Sharavanan, R. Sivaraj, "Antidiabetic effect of Chloroxylon swietenia bark extracts on streptozotocin induced diabetic rats", Beni-Suef University Journal of Basic and Applied Sciences, Vol. 5, p. 61, 2016

DOI: https://doi.org/10.1016/j.bjbas.2016.01.004