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Acute Toxicity and Dose Fixation Studies on Chloroxylon swietenia Dc Bark Extracts on Streptozotocin Induced Diabetic Rats

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Abstract:

Diabetes mellitus (DM) is a chronic metabolic disease with the highest rates of prevalence and mortality worldwide. Chloroxylon swietenia has been used extensively in folkloric medicine. The present study aims to determine the acute toxicity of Chloroxylon swietenia bark methanol (CSBMEt) and aqueous extracts (CSBAEt) (100, 150, 250, 500 and 1000 mg/kg body weight) and dose fixation of CSBMEt and CSBAEt in streptozotocin induced diabetic rats. Diabetes was induced in male albino wistar rats by single intraperitoneal injection of streptozotocin (50mg/kg b.w). The diabetic rats were administered with Chloroxylon swietenia bark extracts (CSBMEt and CSBAEt) (75,125 and 250mg/kg b.w) orally by intragastric intubation for 15 days. Acute toxicity studies revealed the non-toxic nature of the CSBMEt and CSBAEt. No lethality or toxic reactions found at any doses until the end of study, whereas 75 and 125 mg/kg b.w. doses of CSBMEt and CSBAEt produce no significant changes in the diabetic rats and 250mg/kg b.w. of CSBMEt and CSBAEt have significant change in the blood glucose. The results conclude that, there was no toxicity observed up to 1000mg/kg b.w. of both the extracts and 250mg/kg b.w. of CSBMEt and CSBAEt can be used as effective dose to treat diabetes.

Info:

Periodical:
International Letters of Natural Sciences (Volume 48)
Pages:
8-13
DOI:
10.18052/www.scipress.com/ILNS.48.8
Citation:
B. Jayaprasad et al., "Acute Toxicity and Dose Fixation Studies on Chloroxylon swietenia Dc Bark Extracts on Streptozotocin Induced Diabetic Rats", International Letters of Natural Sciences, Vol. 48, pp. 8-13, 2015
Online since:
Nov 2015
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