Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILNS > Volume 47 > Studying the Post-Operatory and Molecular...
< Back to Volume

Studying the Post-Operatory and Molecular Modifications in the Chronic Pancreatitis and Pancreatic Cancer - The Importance of the Micronutrients and Pancreatic Enzyme Supplementation

Full Text PDF

Abstract:

The pancreatic cancer is a disorder with an exponentially increased incidence, especially over the last few years. Moreover, it is estimated that almost 95% of the patients with this disease are presenting to the hospital in the advanced and unresectable stages. Also, over the past few decades the development and advance of the surgical methods and techniques have improved, with the most of the operatory actions in the chronic pancreatitis and pancreatic cancer being represented by the whipple duodeno-pancreatectomy, which in fact represents the standard resection for tumors of the duodenum, as well as the hepatopancreatic ampulla of Vater, distal choledocus and the head of the pancreas. Moreover, it is important to mention that in these cases, after an extended resection and reconstruction of the upper gastrointestinal tract, the digestive physiology will be disrupted. In addition, previous studies have shown that patients can maintain a body mass index after surgery but often this will be lower than its preoperative value. Thus, considering the aforementioned aspects, in the present mini-review we were mainly interested in presenting also the relevance of the micronutrients such as iron, selenium, vitamin D and E, zinc or copper in this complicated area of research, as well as aspects regarding the correlations between immune function and micronutrients or the pancreatic enzyme supplementation.

Info:

Periodical:
International Letters of Natural Sciences (Volume 47)
Pages:
89-96
Citation:
D. Timofte et al., "Studying the Post-Operatory and Molecular Modifications in the Chronic Pancreatitis and Pancreatic Cancer - The Importance of the Micronutrients and Pancreatic Enzyme Supplementation", International Letters of Natural Sciences, Vol. 47, pp. 89-96, 2015
Online since:
Sep 2015
Export:
Distribution:
References:

[1] R. Pezzilli, Screening tests for pancreatic cancer: searching for the early symptoms or the population at risk, Jop. 5 (2004) 240-242.

[2] E. Tamm, Diagnosis, staging, and surveillance of pancreatic cancer, AJR Am J Roentgenol. 180 (2003) 1311-1323.

[3] W. Melvin, Outcome analysis of long-term survivors following pancreaticoduodenectomy, J Gastrointest Surg. 2 (1998) 72-78.

[4] R. McLeod, Quality of life, nutritional status, and gastrointestinal hormone profile following the Whipple procedure, Am J Surg. 169 (1995) 179-185.

[5] T. Armstrong, F. Ruiz-Jasbon, J. SheK, C. Permert, Pancreaticoduodenectomy for periampullary neoplasia leads to specific micronutrient deficiencies, Pancreatology. 7 (2007) 37-44.

DOI: https://doi.org/10.1159/000101876

[6] B. Traş, F. Inal, A. Baş, V. Altunok, M. Elmas, E. Yazar, Effects of continuous supplementations of ascorbic acid, aspirin, vitamin E and selenium on some haematological parameters and serum superoxide dismutase level in broiler chickens, Br Poult Sci. 41 (2000).

DOI: https://doi.org/10.1080/00071660020009225

[7] R. Chandra, Effect of two feeding formulas on immune responses and mortality in mice challenged with Listeria monocytogenes, Immunol Lett. 27 (1991) 45-48.

DOI: https://doi.org/10.1016/0165-2478(91)90242-3

[8] J. Kinsella, B. Lokesh, Dietary lipids, eicosanoids, and the immune system, Crit Care Med. 18 (1990) 94-113.

[9] S. Bengmark, R. Andersson, G. Mangiante, Uninterrupted perioperative enteral nutrition, Clin Nutr. 20 (2001) 11-19.

DOI: https://doi.org/10.1054/clnu.2000.0111

[10] S. Cunningham-Rundles, D. Lin, Nutrition and the immune system of the gut, Nutrition. 14 (1998) 573-579.

DOI: https://doi.org/10.1016/s0899-9007(98)00029-x

[11] M. Berger, Trace element supplementation modulates pulmonary infection rates after major burns: a double-blind, placebo-controlled trial, Am J Clin Nutr. 68 (1998) 365-371.

[12] C. Braunschweig, Parenteral zinc supplementation in adult humans during the acute phase response increases the febrile response, J Nutr. 127 (1997) 70-74.

[13] N. Leone, D. Courbon, P. Ducimetiere, M. Zureik, Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality, Epidemiology. 17 (2006) 308-14.

DOI: https://doi.org/10.1097/01.ede.0000209454.41466.b7

[14] D. Silverman, Risk factors for pancreatic cancer: a case-control study based on direct interviews, Teratog Carcinog Mutagen. 21 (2001) 7-25.

DOI: https://doi.org/10.1002/1520-6866(2001)21:1<7::aid-tcm3>3.0.co;2-a

[15] R. Williamson, Gastric emptying and enterogastric reflux after conservative and conventional pancreatoduodenectomy, Surgery. 114 (1993) 82-86.

[16] M. Muller, Gastric emptying following pylorus-preserving Whipple and duodenum-preserving pancreatic head resection in patients with chronic pancreatitis, Am J Surg. 173 (1997) 257-63.

DOI: https://doi.org/10.1016/s0002-9610(96)00402-3

[17] P. Layer, Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes, Gastroenterology. 98 (1990) 1311-1319.

[18] J. Dominguez-Munoz, Effect of the administration schedule on the therapeutic efficacy of oral pancreatic enzyme supplements in patients with exocrine pancreatic insufficiency: a randomized, three-way crossover study. Aliment Pharmacol Ther. 21 (2005).

DOI: https://doi.org/10.1111/j.1365-2036.2005.02390.x
Show More Hide