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Effect of Mimosa pudica Cured Extract against High Fructose Diet Induced Type 2 Diabetes in Rats

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Abstract:

The study evaluated the effects of Mimusa pudica (M. pudica) leaf extract on type 2 diabetes in rats fed high fructose diet (HFD). Rats were fed either control diet or HFD for 14 days, following which the diet was fortified with M. Pudica at a dose of 500 mg/kg BW. After 8 weeks, HFD caused deleterious metabolic effects, including increased body weight, hyperglycemia, hyperinsulinemia, dyslipidemia and liver dysfunction. Further, rats fed HFD alone showed increased activities of hepatocellular enzymes in plasma and lipid deposition in liver. Treatment with M. pudica significantly reduced the body weight, improved insulin sensitivity, managed the dyslipidemia and reduced liver damage towards normal. Histopathology of the liver confirmed the changes induced by HFD and the M. pudiac treatment significantly reversed towards normality. These data suggest that M. pudica treatment improve insulin sensitivity and attenuates fat accumulation in liver.

Info:

Periodical:
International Letters of Natural Sciences (Volume 39)
Pages:
1-9
Citation:
A. Sundaresan and T. Radhiga, "Effect of Mimosa pudica Cured Extract against High Fructose Diet Induced Type 2 Diabetes in Rats", International Letters of Natural Sciences, Vol. 39, pp. 1-9, 2015
Online since:
May 2015
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Cited By:

[1] G. Muhammad, M. Hussain, I. Jantan, S. Bukhari, "Mimosa pudicaL., a High-Value Medicinal Plant as a Source of Bioactives for Pharmaceuticals", Comprehensive Reviews in Food Science and Food Safety, Vol. 15, p. 303, 2016

DOI: https://doi.org/10.1111/1541-4337.12184