Molecular Aspects of Effect of Shiga Toxin in Humans - A Review

Pal, Partha

doi:10.18052/www.scipress.com/ILNS.34.78

ILNS > Volume 34 > Molecular Aspects of Effect of Shiga Toxin in...

< Back to Volume

Molecular Aspects of Effect of Shiga Toxin in Humans - A Review

Full Text PDF

Abstract:

Shiga toxins belonging to a family of structurally and functionally related protein toxins serve as the key virulence factors for pathogenecity of the virulent enteric bacterial strains namely Shigella dysenteriae serotype 1 including Shiga toxin-producing Escherichia coli (STEC). S. dysenteriae type 1 isolates remain major public health concerns due to their widespread outbreaks and the severity of extra-intestinal diseases, including acute renal failure and also affects the central nervous system. Despite practicing improved hygienic conditions and regulating food and drinking water safety, the enteric pathogens are imposing a major threat in the well being of the human society. Shiga toxin on entry into host cells’ endoplasmic reticulum (ER) activates the stress response in ER and inhibits protein synthesis by catalytic inactivation of eukaryotic ribosomes. In many cell types shiga toxins trigger apoptosis. Recent studies have shown that shiga toxins induce autophagy which activates different signaling pathways in toxin-sensitive and toxin-resistant human cells. In this review the molecular basis of Shiga toxins’ effect on host cell leading to manifestation of the infection in affected individuals are discussed with an emphasis on recent findings.

Info:

Periodical:

International Letters of Natural Sciences (Volume 34)

Pages:

78-89

DOI:

https://doi.org/10.18052/www.scipress.com/ILNS.34.78

Citation:

P. Pal, "Molecular Aspects of Effect of Shiga Toxin in Humans - A Review", International Letters of Natural Sciences, Vol. 34, pp. 78-89, 2015

Online since:

February 2015

Authors:

Partha Pal

Keywords:

Apoptosis, Infection, Shiga Toxins, Shigella dysenteraie, STEC

Export:

RIS, BibTeX, Text

Distribution:

Open Access

This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Allison H.E., Future Microbiol. 2(2007)165-174.

Alperi A., Figueras J., Clin Microbiol Infect 16 (2010) 1563-1567.

Asakura H., Makino S., Shirahata T., Tsukamoto T., Kurazono H., Ikeda T., Takeshi K., Microbiol Immunol 42 (1998) 815-822.

Bentancor A., Rumi M.V., Gentilini M.V., Sardoy C., Irino K., Agostini A., Cataldi A., FEMS Microbiol Lett 267 (2007) 251-256.

Bielaszewska M., et al., Lancet Infect Dis (2011) 11: 671-676.

Bielaszewska M., Idelevich E.A., Zhang W., Bauwens A., Schaumburg F., Mellmann A., Peters G., Karch H., Antimicrob Agents Chemother 56 (2012) 3277-3282.

Boerlin P., et al., J Clin Microbiol 37 (1999) 497-503.

Bopp D.J., Sauders B.D., Waring A.L., Ackelsberg J., Dumas N., Braun-Howland E., Dziewulski D., Wallace B.J., Kelly M., Halse T., et al., J Clin Microbiol 41 (2003) 174-180.

Bridgwater F.A., Morgan R.S., Rowson K.E., Wright G.P., Br. J. Exp. Pathol 36 (1955) 447-453.

Brzuszkiewicz E., et al., Arch Microbiol 193 (2011) 883-891.

Buchholz U., et al., N Engl J Med 365 (2011) 1763-1770.

Carey C.M., Kostrzynska M., Ojha S., Thompson S., J Microbiol Methods 73 (2008)125-132.

Caprioli A., Morabito S., Brugere H., Oswald E., Vet Res 36 (2005) 289-311.

Casas V., Miyake J., Balsley H., Roark J., Telles S., Leeds S., Zurita I., Breitbart M., Bartlett D., Azam F., et al., FEMS Microbiol Lett 261 (2006) 141-149.

Cherla R.P., Lee S.Y., Tesh V.L., FEMS Microbiol. Lett 228 (2003) 159-166.

Cookson A.L., Taylor S.C., Attwood G.T., N Z Vet J 54 (2006) 28-33.

Corte's C., de la Fuente R., Blanco J., Blanco M., Blanco J.E., Dhabi G., Mora A., Justel P., Conteras A., Sanchez A., et al., Vet Microbiol. 110 (2005) 67-76.

Degnan P.H., Moran N.A., Appl. Environ. Microbiol 74 (2008) 6782-6791.

Donohue-Rolfe A., Keusch G.T., Infect. Immun 39 (1983) 270-274.

Duris J.W., Haack S.K., Fogarty L.R., J Environ Qual 38 (2009) 1878-1886.

Endo Y., Tsurugi K., Yutsudo T., Takeda Y., Ogasawara T., Igarashi K., Eur J Biochem 171 (1988) 45-50.

Fattah K.R., Mizutani S., Fattah F.J., Matsushiro A., Sugino Y., Genes Genet Syst 75 (2000) 223-232.

Feldman K.A., Mohle-Boetani J.C., Ward J., Furst K., Abbott S.L., Ferrero D.V., Olsen A., Werner S.B., Public Health Rep 117 (2002) 380-385.

Ferens W., Hovde C.J., Foodborne Pathog Dis 8 (2011) 465-487.

Fernandez D., Rodriguez E.M., Arroyo G.H., Padola N.L., Parma A.E., J Appl Microbiol 106 (2009)1260-1267.

Fratamico P.M., Bhagwat A.A., Injaian L., Fedorka-Cray P.J., Foodborne Pathog Dis 5 (2008) 827-838.

Fraser M.E., Chernaia M.M., Kozlov Y.V., et al., Nat. Struct. Biol (1994) 59-64.

Fraser M.E., Fujinaga M, Cherney M.M., Melton-Celsa A.R., Twiddy E.M., O'Brien A.D., James M.N.G., J. Biol. Chem 279 (2004) 27511-27517.

Galiero G., Conedera G., Alfano D., Caprioli A., Vet Rec 156 (2005) 382-383.

Garred Ø., van Deurs B., Sandvig K.,. J. Biol. Chem 270 (1995) 10817-10821.

Gilbreath J.J., Shields M.S., Smith R.L., Farrell L.D., Sheridan P.P., Spiegel K.M., Appl Environ Microbiol 75 (2009) 862-865.

Grotiuz G., Sirok A., Gadea P., Varela G., Schelotto F., J. Clin. Microbiol 44 (2006) 3838-3841.

Gyles C.L., J. Anim. Sci 85 (2007) 45-62.

Halabi M., Orth D., Grif K., Wiesholzer-Pittl M., Kainz M., Schöberl J., Dierich M.P., Allerberger F., Würzner R., Int J Hyg Environ Health 11 (2008) 454-457.

Haque Q.M., Sugiyama A., Iwade Y., Midorikawa Y., Yamauchi T., Curr. Microbiol 32 (1996) 239-245.

Heuvelink A.E., Van Den Biggelaar F.L.A.M., De Boer E., Herbes R.G., Melchers W.J.G., Huis In'T Veld J.H.J., Monnens L.A.H., J Clin Microbiol 36 (1998) 878-882.

Hughes L.A., Bennett M., Coffey P., Elliott J., Jones T.R., Jones R.C., Lahuerta-Marin A., McNiffe K., Norman D., Williams N.J., et al., Epidemiol Infect. 137 (2009) 1574- 1582.

Hussein H.S., J Anim Sci 85 (2007) E63-E72.

Imamovic L., Balleste E., Jofre J., Muniesa M., Appl Environ Microbiol 76 (2010) 5693-5701.

Iordanov M.S., Pribnow D., Magun J.L., et al., Mol Cell Biol 17 (1997) 3373-3381.

Jackson M.P., Neill R.J., O'Brien A.D., Holmes R.K., Newland J.W., FEMS Microbiol Lett 44 (1987) 109-114.

Jansen A., Kielstein J.T., Euro Surveill 16 (2011).

Jenkins C., Pearce M.C., Chart H., Cheasty T., Willshaw G.A., Gunn G.J., Dougan G., Smith H.R., Synge B.A., Frankel G., J Appl Microbiol 93 (2002) 944-953.

Johannes L., Römer W., Nat Rev Microbiol. 8 (2010)105-116.

Kaplan B.S., Meyers K.E., Schulman S.L. J Am Soc Nephrol 9 (1998) 1126-1133.

Karmali M.A., Petric M., Lim C., Fleming P.C., Arbus G.S., Lior H., J Infect Dis 151 (1985) 775-782.

Karmali M.A., Steele B.T., Petric M., et al., Lancet 1 (1983) 619-620.

Kim Y.J., Kim J.H., Hur J., Lee J.H., Can J Vet Res 74 (2010) 59-64.

Konowalchuk J., Speirs J.I., Stavric S., Infect Immun 18 (1977) 775-779.

Leotta G.A., Deza N., Origlia J., Toma C., Chinen I., Miliwebsky E., Iyoda S., SosaEstani S., Rivas M., Vet Microbiol 118 (2006) 151-157.

Licence K., Oates K.R., Synge B.A., Reid T.M., Epidemiol Infect 126 (2001)135-138.

Lienemann T., Pitkänen T., Antikainen J., Mölsä E., Miettinen I., Haukka K., Vaara M., Siitonen A., Curr Microbiol 62 (2011) 1239-1244.

Lingwood C.A., Binnington B., Manis A., Branch D.R., FEBS Lett 584 (2010) 1879- 1886.

Lord J.M., Roberts L.M., Lencer W.I., Curr Topics Microbiol Immunol 300 (2005) 149-168.

Loukiadis E., Kérourédan M., Beutin L., Oswald E., Brugère H., Appl Environ Microbiol 72 (2006) 3245-3251.

Louise C.B., Obrig T.G., Microvasc Res 47 (1994) 377-387.

Matz C., Kjelleberg S., Trends Microbiol 13 (2005) 302-307.

Mauro S.A., Koudelka G.B., Toxins 3 (2011) 608-625.

McCall B.J., Slinko V.G., Smith H.V., Heel K., Culleton T.H., Kelk V.R., Commun Dis Intell 34 (2010) 54-56.

McCarthy T.A., Barrett N.L., Hadler J.L., Salsbury B., Howard R.T., Dingman D.W., Brinkman C.D., Bibb W.F., Cartter M.L., Pediatrics 108 (2001) E59.

Mellmann A., et al., PLoS One 6 (2011) e22751.

Menrath A., Wieler L.H., Heidemanns K., Semmler T., Fruth A., Kemper N., Gut Pathog 2 (2010) 7.

Moazzezy N., Oloomi M., Bouzari S., Int J Mol Cell Med Spring 3(2) (2014) 108-117.

Moore M.A., Blaser M.J., Perez-Perez G.I., O'Brien A.D., Microb Pathog 4 (1988) 455-462.

Muniesa M., Jofre J., García-Aljaro C., Blanch A.R., Environ Sci Technol 40(2006) 7141-7149.

Muniesa M., Jofre J., FEMS Microbiol Lett 183 (2000) 197-200.

Nakagawa I., Nakata M., Kawabata S., Hamada S., Mol Microbiol 33 (1999) 1190- 1199.

Obata F., Adv Appl Microbiol 71 (2010) 1-19.

O'Brien A.D., LaVeck G.D., Thompson M.R., Formal S.B., J Infect Dis 146 (1982)763-769.

O'Brien A.D., Tesh V.L., Donohue-Rolfe A., Jackson M.P., Olsnes S., Sandvig K., Lindberg A.A., Keusch G.T., Curr Top Microbiol Immunol 180(1992) 65-94.

Oliveira M.G., Brito J.R., Carvalho R.R., Guth B.E., Gomes T.A., Vieira M.A., Kato M.A., Ramos II Vaz T.M., Irino K., Appl Environ Microbiol 73 (2007) 5945-5948.

Paton A.W., Paton J.C., J Clin Microbiol 34 (1996) 463-465.

Paunio M., Pebody R., Keskimäki M., Kokki M., Ruutu P., Oinonen S., Vuotari V., Siitonen A., Lahti E., Leinikki P., Epidemiol Infect 122 (1999) 1-5.

Perna N.T., Plunkett G III., Burland V., Mau B., Glasner J.D., Rose J.D., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A., et al., Nature 409(2001) 529-533.

Petruzziello-Pellegrini T.N., Marsden P.A., Curr Opin Nephrol Hypertens 21 (2012) 433-440.

Petruzziello-Pellegrini T.N., Yuen D.A., Page A.V., Patel S., Soltyk A.M., Matouk C.C., Wong D.K., Turgeon P.J., Fish J.E., Ho J.J., et al., J Clin Invest 122 (2012) 759776.

Petruzziello-Pellegrini T.N., Moslemi-Naeini M., Marsden P.A., Virulence 4 (6) (2013)556-563.

Phillips A.D., et al., Gut 47 (2000) 377-381.

Proulx F., Tesh V.L., Pediatric Critical Care Medicine: Basic Science and Clinical Evidence. London: Springer-Verlag (2007) 1198-1204.

Ram S., Vajpayee P., Shanker R., Environ Health Perspect 116 (2008) 448-452.

Ram S., Vajpayee P., Shanker R., Environ Sci Technol 41 (2007) 7383-7388.

Riley L.W., Remis R.S., Helgerson S.D., McGee H.B., Wells J.G., Davis B.R., Hebert R.J., Olcott E.S., Johnson L.M., Hargrett N.T., et al., New Engl J Med 308 (1983) 681- 685.

Rogerie F., Marecat A., Gambade S., Duponda F., Beauboisb P., Lange M., Int J Food Microbiol 63 (2001) 217-223.

Römer W., Berland L., Chambon V., Gaus K., Windschiegl B., Tenza D., et al., Nature 450 (2007) 670-675.

Rosales A., Hofer J., Zimmerhackl L.B., Jungraithmayr T.C., Riedl M., Giner T., Strasak A., Orth-Höller D., Würzner R., Karch H., German-Austrian HUS Study Group., Clin Infect Dis 54 (2012) 1413-1421.

Sánchez S, García-Sánchez A, Martínez R, Blanco J, Blanco J, E, Blanco M, Dahbi G., Mora A., Hermoso de Mendoza J., Alonso J.M., et al., Vet J 180 (2009) 384-388.

Sánchez S., Martínez R., García A., Vidal D., Blanco J., Blanco M., Blanco J.E., Mora A., Herrera-León S., Echeita A., et al., Vet. Microbiol 143 (2010) 420-423.

Sandvig K., Garred O., Prydz K., et al., Nature 358 (1992) 510-512.

Sandvig K., Bergan J., Dyve A.B., Skotland T., Torgersen M.L., Toxicon 56 (2010) 1181-1185.

Sato T., Shimizu T., Watarai M., Kobayashi M., Kano S., Hamabata T., Takeda Y., Yamasaki S., J Bacteriol 185 (2003) 3966-3971.

Scheiring J., Andreoli S.P., Zimmerhackl L.B., Pediatr Nephrol 23 (2008) 1749- 1760.

Schmidt H., Montag M., Bockemuhl J., Heesemann J., Karch H., Infec Immunol 61 (1993) 534-543.

Schüller S., Toxins 3 (2011) 626-639.

Siegler R.L., J Pediatr 1994. Vol. 125 (1994) 511-518.

Scotland S.M., Smith H.R., Rowe B., Lancet 2 (1985) 885-886.

Smith C.J., Olszewski A.M., Mauro S.A., Appl Environ Microbiol 75 (2009) 316-21.

Stein P.E., Boodhoo A., Tyrrell G.J., et al., Nature 355 (1992) 748-750.

Strockbine N.A., Jackson M.P., Sung L.M., Holmes R.K., O'Brien A.D., J Bacteriol Vol. 170 (1988) 1116-1122.

Strockbine N.A., Marques L.R., Newland J.W., Smith H.W., Holmes R.K., O'Brien A.D., Infect Immunol 53(1986) 135-140.

Swerdlow D.L., Woodruff B.A., Brady R.C., Griffin P.M., Tippen S., Donnell HDJr., Geldreich E., Payne B.J., Meyer AJr,. Wells J.G., et al., Ann Intern Med 117 (1992) 812-819.

Tam P.J., Lingwood C.A., Microbiology 153 (2007) 2700-2710.

Tarr P.I., Gordon C.A., Chandler W.L., Lancet 365 (2005) 1073-1086.

Tesh V.L., Future Microbiol 5 (2010) 431-453.

Trachtman H., Austin C., Lewinski M., Stahl R.A., Nat Rev Nephrol 8 (2012) 658-669.

Urdahl A.M., Beutin L., Skjerve E., Zimmermann S., Wasteson Y., J Appl Microbiol 95 (2003) 92-101.

Varma J.K., Greene K.D., Reller M.E., DeLong S.M., Trottier J., Nowicki S.F., DiOrio M., Koch E.M., Bannerman T.L., York S.T., et al., J Am Med Assoc 290 (2003) 2709- 2712.

Vernon L.T., Cell Microbiol 14(1) (2012) 1-9.

Vu-Khac H., Cornick N.A., Vet Microbiol 126 (2008) 356-363.

Wani S.A., Samantha I., Munshi Z.H., Bhat M.A., Nishikawa Y., J Appl Microbiol 100 (2006) 108-113.

Walters S.P., Thebo A.L., Boehm A.B., Water Res 45 (2011) 1752-1762.

Yan Y., Shi Y., Cao D., Meng X., Xia L., Sun J., Curr Microbiol 62 (2011) 458-464.

Yatsuyanagi J., Saito S., Ito I., Jpn J Infect Dis 55 (2002) 174-176.

Zoja C., Buelli S., Morigi M., Pediatr Nephrol 25 (2010) 2231-2240. ( Received 08 February 2015; accepted 15 February 2015 ).

Show More Hide

Cited By:

[1] M. Golshani, M. Oloomi, S. Bouzari, "In silico analysis of Shiga toxins (Stxs) to identify new potential vaccine targets for Shiga toxin-producing Escherichia coli ", In Silico Pharmacology, Vol. 5, 2017

DOI: https://doi.org/10.1007/s40203-017-0022-4

[2] J. Smith, N. Gunther IV, "Commentary: Campylobacter and Hemolytic Uremic Syndrome", Foodborne Pathogens and Disease, 2018

DOI: https://doi.org/10.1089/fpd.2018.2513