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Abortifacient and Antioxidant Activities of Avicennia marina

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The current study was intended to evaluate abortifacient and antioxidant activity of Avicennia marina leaves extracts. Abortifacient activity was evaluated in rats, compared with standard drug (Mifepristone) and antioxidant activity was evaluated by using three free radicals (Superoxide, Hydroxyl and DPPH) compared with Ascorbic acid. The extracts were showed pre implantation loss, post implantation loss of implantations and decreased the survival ration of foetuses. Among all extracts hydroalcoholic extract showed better activity. The selected plant extracts showed concentration dependent percentage inhibition of free radicals. Among three extracts hydroalcoholic extract showed better activity with IC50 values on superoxide, hydroxyl and DPPH radicals were 203μg, 237μg and 143μg. From the results obtained during the study it the hydroalcoholic extract was used for the isolation of pure compounds, and isolated the different compounds (β-sitosterol, Lupeol and Betulinic acid).


International Letters of Natural Sciences (Volume 33)
M. Srikanth et al., "Abortifacient and Antioxidant Activities of Avicennia marina", International Letters of Natural Sciences, Vol. 33, pp. 12-26, 2015
Online since:
January 2015

Iwu MW, Duncan AR, Okunji CO. 1999. New antimalarials of plant origin. In: Janick J, editor. Perspective on new crops and new uses. Alexandria: VA ASHS Press. pp.457-462.

Rakesh. K, Sharma and Rajesh Arora. 2006. Herbal Drugs. Jaypee Brothers Medical Publishers, 1st Edn.

Gunasekera, R.M.; shim, K.F.; lam, T.J. 1995. Effects of dietary protein level on puberty, oocyte growth and egg chemical composition in the tilapia, Oreochromis niloticus (L. ). Aquaculture, v. 134, pp.169-183.

Christine-Maitre S, Vasseur C, Bouchard P, 1998. Genes and premature ovarian failure. Mol. Cell. Endocrinol. 145: 75-80.

Cigand C, Laborde A. 2003. A herbal infusion used for induced abortion. J Toxicol Clin Toxicol. 41: 235-239.

Kavindra Kumar Kesari and Jitendra Behari 2010. Microwave Exposure Affecting Reproductive System in Male Rats. Applied Biochemistry and Biotechnology, 162; (2): 416-428.

Salhab AS, Al-Tamimi SO, Gharaibeh MN, et al., 1998. The abortifacient effects of castor bean extract and ricin Achain in rabbit. Contraception; 58(3): 193-7.

Yakubu MT, Adeshina AO, Oladiji AT, Akanji MA, Oloyede OB, Jimoh GA, Olatinwo AWO, Afolayan AJ. 2010. Abortifacient Potential of Aqueous Extract of Senna alata Leaves in Rats, Journal of Reproduction and Contraception. 21 (3): 163-177.

Dinesh Dabhadkar and Varsha Zade. 2012. Abortifacient activity of Plumeria rubra (Linn) pod extract in female albino rats, Indian Journal of Experimental Biology. 50 (10): 702-707.

Elbetieha A, Oran S A, Alkofahi A, Darmani H & Raies A M. 2000. Fetotoxic potential of Globularia arabica and Globularia alypum (Globulariaceace) in rats. J Ethnopharmacol,; 72: 215.

Srikanth M., T. Rajananda Swamy, T. Mallikarjuna Rao, B. Ganga Rao. 2013. Abortifacient and antioxidant activities of different extracts of Musa rosacea, Asian Pacific Journal of Reproduction; 1(3): 174-177.

Sandhya B, Thomas S, Isabel W, Shenbagarathai R 2006. Ethnomedicinal plants used by the Valaiyan community of Piranmalai Hills (Reserved Forest), Tamil Nadu, India. A pilot study. Afr. J. Traditional Complementary Altern. Med. 3(1): 101- 114.

Prayaga Murthy, Venkaiah. 2010. Some abortifacient plants used by the tribal people of Andhra Pradesh, India. Journal of Phytology, 2(4): 7-12.

Ganga Rao. B, Umamaheswara Rao. P, Sambasiva Rao. E, Mallikarjuna Rao. T, V.S. Praneeth.D. 2011. Studies on Phytochemical Constituents, Quantification of Total Phenolic, Alkaloid Content and In-vitro Anti-oxidant Activity of Thespesia populnea Seeds, Free Radicals and Antioxidants,; 1(4): 56-61.

Sambasiva rao. Ethadi, Pragada. Rajeswara rao, Battu. Ganga rao and Mallikarjuna rao Talluri, 2013. Antiinflammatory and antibacterial activities of Different extracts of Gynandropsis gynandra, Int J Pharm Pharm Sci, Vol 5, Suppl 4, 162-165.

Mallikarjuna Rao T., B. Ganga Rao, Y. Venkateswara Rao, Antioxidant activity of Spilanthes acmella Extracts International Journal of Phytopharmacology. 2012; 3(2): 216-220.

Mallikarjuna Rao T., B. Ganga Rao, Y. Venkateswara Rao, Hepatoprotective and antioxidant capacity of Melochia corchorifolia Extracts, Asian Pacific Journal of Tropical Medicine 2013; 6 (7): 412-420.

S Kalidas, B Kameswari, P Devi, B Madhumitha, R Meera, NJ Merlin, 2008. PhytoPhysico chemical evaluation, Antioxidant activities and Diuretic activity of Leaves of Lagerstroemia reginae. Asian J. Research Chem 1(2): 83-87.

Mc Cord JM, Fridovich I. 1969. Superoxide dismutase: an enzymic function for erythrocuprein (hemocuprien). J Biol Chem. 244: 6049-6055.

Braca A, Fico G, Morelli I, De Simone F, Tome F, De Tommasi N. 2003. Antioxidant and free radical scavenging activity of flavonol glycosides from different Aconitum species. J Ethnopharmacol. 86: 63-67.

Anita Murali, Purnima Ashok, Madhavan V. 2011. In vitro antioxidant activity and HPTLC Studies on the roots and rhizomes of Smilax zeylanica L. (smilacaceae). Int J Pharm Pharm Sci. 3(1): 192-195.

Shrestha J, Shanbhag T, Shenoy S, Amuthan A, Prabhu K, Sharma S, Banerjee S, Kafle S. 2010. Antiovulatory and abortifacient effects of Areca catechu (betel nut) in female rats. Indian J Pharmacol. 42: 306-11.

Koneri R, Balaram R, Saraswati CD. 2006. Antiovulatory and abortifacient potential of the ethanolic extract of roots of Momordica cymbalaria fenzl in rats. Indian J Pharmacol, 38: 111-4.

Musa T. Yakubu and Bimbo B. Bukoye. Abortifacient potentials of the aqueous extract of Bambusa vulgaris leaves in pregnant Dutch rabbits, Contraception 2009; 80: 308-313.

Emmanuel Noumi and Claudette Djeumen. 2007. Abortifacient plants of the Buea region, their participation in the sexuality of adolescent girls, Indian Journal of Traditional Knowledge; 6(3): 502-507.

Ghulam Mujtaba Shah, Mir Ajab Khan, Dr. Mushtaq Ahmad, Muhammad Zafar and Aftab Ahmed Khan. 2009. Observations on antifertility and abortifacient herbal drugs, African Journal of Biotechnology; 8 (9): 1959-(1964).

Yeung, H.W., Li, W.W., Chan, W.Y., Law, L.K. and Ng, T.B. 1986. Alpha and beta momor- charins: abortifacient proteins from seeds of the bitter gourd Momordica chamntia (family Cucurbitaceae). International Journal of Peptide and Protein Research 28, 518-524.

Siddiqui MB, Alam MM, Hussain W, Sharma GK. 1998. Ethnobotanical study of plants used for terminating pregnancy. Fitoterapia 59: 250- 252.

Sing VK, Ali ZA. 1996. Folk Medicinal Plants used for family planning in India. Ethnobiology in human welfare, Jain SK (Ed. ), Deep Publication, New Delhi, pp.184-186.

Katalinic V, Milos M, Kulisic T, Jukic M. 2006. Screening of 70 medicinal plant extracts for antioxidant capacity and total phenols. Food Chem; 94: 550-557.

Riddle, John M. Eve's Herbs - A History of Contraception and Abortion in the West, Harvard University Press, Cambridge MA, (1997).

Maestri DM, Nepote V, Lamarque AL, Zygadlo JA. 2006. Natural products as antioxidants. Phytochemistry: Advances in research. Trivandrum: Research Signpost;, 105-135.

Ashwell R Ndhlala, Mack Moyo, Johannes Van Staden. 2010. Natural antioxidants: fascinating or mythical biomolecules? Molecules; 15: 6905-6930.

Edwin N. Frankel, John W Finley. 2008. How to standardize the multiplicity of methods to evaluate natural antioxidants. J Agric Food Chem; 56: 4901-4908.

Djeridane A, Yousfi M, Nadjemi B, Boutassouna D, Stocker P, Vidal N. 2006. Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem; 97: 654-660. ( Received 17 January 2015; accepted 26 January 2015 ).

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