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Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models

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Abstract:

The present investigation was carried out to evaluate the hypolipidemic activity of methanolic and aqueous leaf extracts of Cassia fistula (CF) Linn (Family: Fabaceae) on atherogenic diet (2% cholesterol, 1% Choline Chloride and 2% Lard) induced Male Sprauge-Dawley rats for the period of 21 days. The rats receiving the treatment with leaf methanol and aqueous extract of CF showed significant (P < 0.001) reduction in total cholesterol (TC), triglycerides (TG), High density lipoprotein (HDL), lipid peroxidation (LPO) and other parameters at dose dependent manner but the effect was less than the standard drug Atorvastatin. The results revealed the effectiveness of CF plant against hyperlipidemic activity.

Info:

Periodical:
International Letters of Natural Sciences (Volume 30)
Pages:
30-43
DOI:
10.18052/www.scipress.com/ILNS.30.30
Citation:
G. V. Sutar et al., "Screening of Different Leaf Extracts of Cassia fistula Linn for Investigation of Hypolipidemic Activity in Two Different Rat Models", International Letters of Natural Sciences, Vol. 30, pp. 30-43, 2015
Online since:
Dec 2014
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