Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILNS > ILNS Volume 24 > Anti-Dermatophytic Activity of Garlic (Allium...
< Back to Volume

Anti-Dermatophytic Activity of Garlic (Allium sativum) Extracts on some Dermatophytic Fungi

Full Text PDF


Dermatophytic infection is a common infection that constitutes public health problem among children. Anti dermatophytic activity of aqueous, ethanolic and methanolic extracts of garlic (Allium sativum) was investigated against isolates of dermatophytic fungi obtained from sixty primary school children in Aba. The well in agar diffusion technique was used to determine the sensitivity patterns of the test organisms. The results were compared with the activity of a known antifungal drug nystatin. The isolates included Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum gypseum, Trichophyton verrucosum and Epidermophyton floccosum. The result of the antifungal activity of garlic showed high but varied levels of antifungal effectiveness on the different species of the dermatophytes at four different concentrations of 12.5 %, 25 %, 50 % and 100 % used. T. rubrum was the most susceptible followed by M. gypseum, T. mentagrophytes, T. verrucosum and E. floccosum respectivey. The diameter zones of inhibition exhibited by the extracts against test fungal species ranged between 4.50 mm and 30.67 mm. Further purification and extraction of active principle of garlic would give an antidermatophytic activity comparable to standard antifungal drugs


International Letters of Natural Sciences (Volume 24)
K. A. Mercy et al., "Anti-Dermatophytic Activity of Garlic (Allium sativum) Extracts on some Dermatophytic Fungi", International Letters of Natural Sciences, Vol. 24, pp. 34-40, 2014
Online since:
August 2014

[1] Aala F., Yusuf U.K., Khodavandi A., Jamal F., Afr J of Microbiol Res 4 (5) (2010) 380-385.

[2] Adefemi S.A., Odeigah L.O., Alabi K.M., Clin. Dermatol. 28 (2011) 197-201.

[4] Amin M., Kapadnis B.P., Ind. J. Exp. Biol, 43 (2005) 751-754.

[5] Balakumar S., Rajan S., Thirunalasundari T., Jeeva S., Asian Pac J Trop Biomed 1(4) (2011) 309-312.

[6] Bhadauria S., Kumar P., Indian J of Fundamental App Life Sci. 1(2) (2011) 1-10.

[7] Doherty V.F., Olaniran O.O., Kanife U.C., Inter J Bio 2(2) (2010) 126-131.

[8] Feresin G.E., Tapia A., Lopez S.N., Zacchino S.A., J Ethnopharmacol 78(1) (2001) 103-107.

[9] Ghahfarokhi M.S., Shokoohamiri M.R., Amirrajab N., Moghadasi B., Ghajari A., Zeini F., Sadeghi G., Razzaghi-Abyaneh M., Fitoterapia 77 (2006) 321-323.


[10] Gherbawy, Y.A.M.H., Acta-Mycologic 31 (1996) 87-99. 85.

[11] Gulsen G., Erol A., Journal of Animal and Vet Adv. 9(1) (2010) 4.

[12] Harris J.C., Cottrell S.L., Plummer S., Lloyd D., Appl. Microbiol. Biotechnol 57 (2010) 282-286.

[13] Kader H.A.A., Seddek S.R., El-Shanawany A A., Assiut Vet Med J, 34 (1995) 36-42.

[14] Jaber M.A., Al-Mossawi A., Afr. J. Biotechnol, 6(6) (2007) 771-777.

[15] Lino A., Deogracious O., Afr. Health Sci. 6(1) (2006) 31-35.

[16] Narula N., Sareen S., Journal of Soil Science 1(1) (2011) 12-15.

[17] Natarajan V., Venugopal P.V., Menon T., Indian J. Med. l Microb. 21 (2003) 98-101.

[18] Nweze E.I., Revista Iberoamericana de Micol. 27(4) (2010) 191-194.

[19] Seebacher C., Bouchara J.P., Mignon B., Mycopathologia. 166 (2008) 335‐352.

[20] Silva M.R. et al., Mycoses 48(3) (2005) 172-175.

[21] Sofowora A. (2008). Medicinal plants and Traditional medicine in Africa, 3rd Ed. Spectrum books ltd Ibadan Nigeria.

[22] Tadeg H., Mohammed E., Asres K., Gebre-Mariam T., J Ethnopharmacol 100(1-2) (2005) 168-175.

[23] Vaijayantimala J., Rajendra Prasad N., Pugalendi K.V., Indian J Microbiol 41 (2001) 325-328. ( Received 14 August 2014; accepted 22 August 2014 ).

Show More Hide
Cited By:

[1] P. Sitarek, A. Merecz-Sadowska, T. Kowalczyk, J. Wieczfinska, R. Zajdel, T. Śliwiński, "Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms", International Journal of Molecular Sciences, Vol. 21, p. 5105, 2020


[2] E. Genatrika, E. Sundhani, M. Oktaviana, "Gel potential of red onion (Allium cepa L.) ethanol extract as antifungal cause tinea pedis", Journal of Pharmacy And Bioallied Sciences, Vol. 12, p. 733, 2020