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ILNS > Volume 22 > Role of Cholera Toxin in Vibrio cholerae Infection...
Role of Cholera Toxin in <i>Vibrio cholerae</i> Infection in Humans - A Review
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Role of Cholera Toxin in Vibrio cholerae Infection in Humans - A Review

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Abstract:

Vibrio cholerae, the causative agent of Asiatic cholera, is a gram-negative motile bacterial species acquired via oral ingestion of contaminated food or water sources. Cholera has spread from the Indian subcontinent where it is endemic to involve nearly the whole world seven times during the past 185 years. V. cholerae serogroup O1, biotype El Tor, has moved from Asia to cause pandemic disease in Africa and South America during the past 35 years. A new serogroup, O139, appeared in south Asia in 1992, has become endemic there, and threatens to start the next pandemic. The facultative human pathogen V. cholerae represents a paradigm that evolved from environmental non-pathogenic strains by acquisition of virulence genes. The major virulence factors of V. cholerae, cholera toxin (CTX) encoded by the ctxAB genes residing in the genome of filamentous lysogenic bacteriophage (CTXɸ) and toxin coregulated pilus (TCP) encoded by vibrio pathogenicity island (VPI). CTX, a potent stimulator of adenylate cyclase, causes the intestine to secrete watery fluid rich in sodium, bicarbonate, and potassium, in volumes far exceeding the intestinal absorptive capacity, by ADP-ribosylation of the alpha subunit of the GTP-binding protein. Thus intestinal infection with V. cholerae results in the loss of large volumes of watery stool, leading to severe and rapidly progressing dehydration and shock. Without adequate and appropriate rehydration therapy, severe cholera kills about half of affected individuals. Today, cholera still remains a burden mainly for underdeveloped countries, which cannot afford to establish or to maintain necessary hygienic and medical facilities. During the last three decades, intensive research has been undertaken to unravel the virulence properties and to study the epidemiology of this significant human pathogen. This review provides an overview of the role of CTX in the occurrence of this disease in humans.

Info:

Periodical:
International Letters of Natural Sciences (Volume 22)
Pages:
22-32
DOI:
https://doi.org/10.18052/www.scipress.com/ILNS.22.22
Citation:
P. Pal "Role of Cholera Toxin in Vibrio cholerae Infection in Humans - A Review", International Letters of Natural Sciences, Vol. 22, pp. 22-32, 2014
Online since:
August 2014
Authors:
Partha Pal
Keywords:
Bacteriophage, Cholera Infection, CTX Phage, Humans, TCP, Vibrio cholerae
Export:
RIS, BibTeX, Text
Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Alama M. etal., Proc Natl Acad Sci USA 111 (2014) 9917-9922.

Albert M.J. etal., Lancet 342 (1993a) 387-390.

Albert M.J., Siddique A.K., Islam M.S., Faruque A.S.G., Ansaruzzaman M., Faruque S.M., Sack R.B., Lancet 341 (1993b) 704.

Baumann P., Furniss A.L., Lee J.V., Bergey's Man Sys Bact 1 (1984) 518-538.

Bik E.M., Bunschoten A.E., Gouw R.D., Mooi F.R., EMBO J 14(1995) 209-216.

Brenner D.J., Krieg N.R., Staley J.T., Bergey's Man Systematic Bacteriology 2 (2005) 491-546.

Cassel D., Selinger Z., Proc Natl Acad Sci USA 74 (1977) 3307-3311.

Chakraborty S. et al., Appl Environ Microbiol 66 (2000) 4022-4028.

Chang E.B., Rao M.C., Diarrheal diseases Elsevier New York (1991) 49-72.

Comstock L.E., Johnson J.A., Michalski J.M., Morris J.G. Jr., Kaper J.B., Mol Microbiol 19 (1996) 815-826.

de Jonge H., Molecular pathogenesis of gastrointestinal infections Plenum Press New York (1991) 107-114.

De S.N., Nature (London) 183 (1959) 1533-1534.

Dizon J.J., W.B. Saunders Co. Philadelphia (1974) 367-379.

Donta S.T., Beristain S., Tomicic T.K., Infect Immun 61 (1993) 3282-3286.

Dutta N.K., Panse M.W., Kulkarni D.R., J Bacteriol 78 (1959) 594-595.

Faruque S.M., Saha Asadulghani M.N., Sack D.A., Sack R.B., Takeda Y., Nair G.B., J Infect Dis 182 (2000a) 1161-1168.

Faruque S.M., Saha Asadulghani M.N., Rahman M.M., Waldor M.K., Sack D.A., Infect Immun 68 (2000b) 4795-4801.

Field M., Physiology of the gastrointestinal tract Raven Press New York (1981) 963-982.

Field M., N Engl J Med 284 (1971) 1137-1144.

Field M., Fromm D., Wallace C.K., Greenough W.B. III., J Clin Invest 48 (1969) 24.

Finkelstein R.A., Plenum Medical Book Co. New York 3 (1992) 155-187.

Finkelstein R.A., LoSpalluto J.J., J Exp Med 130 (1969) 185-202.

Galen J.E., Ketley J.M., Fasano A., Richardson S.H., Wasserman S.S., J Kaper. B., Infect Immun 60 (1992) 406-415.

Gill D.M., King C.A., J Biol Chem 250 (1975) 6424-6432.

Gill D.M., Rappaport R.S., J Infect Dis 139 (1979) 674-680.

Griffiths S.L., Finkelstein R.A., Critchley D.R., Biochem J 238 (1986) 313-322.

Hall R.H., Khambaty F.M., Kothary M., Keasler S.P., Lancet 342 (1993) 430.

Hirst T.R., Sourcebook of bacterial protein toxins Academic Press London (1991) 75-100.

Holmgren J., Lonnroth I., Mansson J., Svennerholm L., Proc Natl Acad Sci USA 72 (1975) 2520-2524.

Hughes J.M., Hollis D.G., Gangarosa E.J., Weaver R.E., Ann Intern Med 88 (1978) 602-606.

Jiang S., Chu W., Fu W., Appl Environ Microbiol 69 (2003) 7541-7544.

Jiang S.C., Matte M., Matte G., Huq A., Colwell R.R., Appl Environ Microbiol 66 (2000) 148-153.

Kahn R.A., Gilman A.G., J Biol Chem 259 (1984) 6235-6240.

Kamruzzaman M., Robins W.P., Bari S.M., Nahar S., Mekalanos J.J., Faruque S.M., Infect Immun Epub (2014).

Kaper J.B., Moseley S.L., Falkow S., Infect Immun 32 (1981) 661-667.

Kaper J.B., Morris J.G. Jr, Levine M.M., Clin Microbiol Rev 8 (1995) 48-86.

Karaolis D.K., Johnson J.A., Bailey C.C., Boedeker E.C., Kaper J.B., Reeves P.R., Proc Natl Acad Sci USA 95 (1998) 3134-3139.

Karaolis D.K., Somara S., Maneval Jr D.R., Johnson J.A., Kaper J.B., Nature 399 (1999) 375-379.

Kelly M.T., Hickman-Brenner F.W., Farmer III J.J., Man Clin Microbiol 5 (1991) 384-395.

King C.A., van Heyningen W.E., J Infect Dis 127 (1973) 639-647.

Koch R., Br Med J (1884) 403-407.

Lencer W.I., de Almeida J.B., Moe S., Stow J.L., Ausiello D.A., Madara J.L., J Clin Invest 92 (1993) 2941-2951.

Lencer W.I., Delp C., Neutra M.R., Madara J.L., J Cell Biol 117 (1992) 1197-1209.

Levine M.M., Black R.E., Clements M.L., Cisneros L., Saah A., D. Nalin R., Gill D.M., Craig J.P., Young C.R., Ristaino P., J Infect Dis 145 (1982) 296-299.

Li M., Kotetishvili M., Chen Y., Sozhamannan S., Appl Environ Microbiol 69 (2003) 1728-1738.

Manning P.A., Stroeher U.H., Morona R., ASM Press Washington D.C. (1994) 77-94. Monsur K.A., Bull W.H. O 28 (1963) 387-389.

Miller-Podraza H., Bradley R.M., Fishman P.H., Biochemistry 21 (1982) 3260-3265.

Miller V.L., Mekalanos J.J., Proc Natl Acad Sci USA 81 (11) (1984) 3471-3475.

Morris J.G. Jr., Epidemiol Rev 12 (1990) 179-191.

Morris J.G., Black Jr.R.E., N Engl J Med 312 (1985) 343-350.

Morris J.G., Picardi Jr.J.L., Lieb S., Lee J.V., Roberts A., Hood M., Gunn R.A., Blake P.A., J Clin Microbiol 19 (1984) 296-297.

Morris J.G. Jr., Wilson R., Davis B.R., Wachsmuth I.K., Riddle C.F., Wathen H.G., Pollard R.A., Blake P.A., Ann Intern Med 94 (1981) 656-658.

Moss J., Vaughan M., Mol Microbiol 5 (1991) 2621-2627.

Nair G.B. et al., J Clin Microbiol 44(11) 4211-4213.

Nair G.B., Oku Y., Takeda Y., Ghosh A., Ghosh R.K., Chattopadhyay S., Pal S.C., Kaper J.B., Takeda T., Appl Environ Microbiol 54 (1988) 3180-3182.

Nair G.B., Takeda Y., World J Microbiol Biotechnol 9 (1993) 299-400.

Nambiar M.P., Oda T., Chen C., Kuwazuru Y., Wu H.C., J Cell Physiol 154 (1993) 222-228.

Pal S.C., Plenum Medical Book Co. New York 3 (1992) 229-251.

Peek J.A., Taylor R.K., Proc Natl Acad Sci USA 89 (1992) 6210-6214.

Peterson J.W., Hejtmancik K.E., Markel D.E., Craig J.P., Kurosky A., Infect Immun 24 (1979) 774-779.

Pierce N.F., J Exp Med 137 (1973) 1009-1023.

Pollitzer R., W.H. O Geneva (1959).

Ramamurthy T., Garg S., Sharma R., Bhattacharya S.K., Nair G.B., Shimada T., Takeda T., Karasawa T., Kurazano H., Pal A., Takeda Y., Lancet 341 (1993) 703-704.

Rao B.M., Surendran P.K., Lett Appl Microbiol 51 (2010) 65-74.

Rao B.M., Surendran P.K., J Food Sci Technol 50(3) (2013) 496-504.

Rennels M.B., Levine M.M., Daya V., Angle P., Young C., J Infect Dis 142 (1980) 328-331.

Rhine J.A., Taylor R.K., Mol Microbiol 13 (1994) 1013-1020.

Rivera I.N.G., Chun J., Huq A., Sack R.B., Colwell R.R., Appl Environ Microbiol 67 (2001) 2421-2429.

Said B., Scotland S.M., Rowe B., J Med Microbiol 40 (1994) 31-36.

Sakazaki R., Plenum Medical Book Co. New York 3 (1992) 37-55.

Shimada T., Nair G.B., Deb B.C., Albert M.J., Sack R.B., Takeda Y., Lancet 341 (1993) 1347.

Shimada T., Sakazaki R., Fujimara S., Niwano K., Mishina M., Takizawa K., Jpn J Med Sci Biol 43 (1990) 37-41.

Sixma T.K., Pronk S.E., Kalk K.H., Wartna E.S., van Zanten B.A.M., Witholt B., Hol W.G.J., Nature (London) 351 (1991) 371-377.

Spangler B.D., Microbiol Rev 56 (1992) 622-647.

Staerk J., Ronneberger H.J., Wiegandt H., Behring Inst Mitt 55 (1974) 145-146.

Svennerholm A. -M., 43rd Nobel Symposium, Stockholm 1978 S Karger Basel (1980) 171-184.

Tacket C.O., Taylor R.K., Losonsky G., Lim Y., Nataro J.P., Kaper J.B., Levine M.M., Infect Immun 66 (1998) 692-695.

Tamura K., Shimoda S., Prescott L.M., Jpn J Med Sci Biol 24 (1971) 125-127.

Taylor R.K., Miller V.L., Furlong D.B., Mekalanos J.J., Proc Natl Acad Sci USA 84 (1987) 2833-2837.

van Heyningen W.E., Seal J.R., Westview Press Boulder Colo (1983).

Waldor M.K., Friedman D.I., Curr Opin Microbiol 8(4) (2005) 459-465.

Waldor M.K., Mekalanos J.J., Science 272 (1996) 1910-(1914).

Waldor M.K., Mekalanos J.J., Lancet 343 (1994) 1366.

Yu J., Webb H., Hirst T.R., Mol. Microbiol 6 (1992) 1949-1958. ( Received 24 July 2014; accepted 04 August 2014 ).

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