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Synthesis, Characterization and Biological Evaluation of 3'-Benzoyl-5'-(Furan-2-yl)-4'-Phenylspiro[Indoline-3,2'-Pyrrolidin]-2-One Derivatives and its Molecular Docking Studies

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Abstract:

A series of new spirooxindole derivatives were synthesized via 1,3 –dipolar cycloaddition. All the synthesized compounds were evaluated for antimicrobial activity. In antibacterial studies compound 4d demonstrated the most potent inhibitory activity (MIC = 12.5 lg/mL for K.pneumonia, B.cereus and S.typhi), which was compared with the positive control streptomycin. In antifungal studies compound 4e demonstrated the most potent inhibitory activity (MIC = 3.125 lg/mL for C.albicans and A.niger), which was related with the standard drug ketaconazole. In addition, molecular modeling studies were also performed to disclose the binding modes of the most active inhibitors to the amino acid residues that compose the active site of the glucosamine-6-phosphate synthase and crystal structure of human lanosterol 14-alpha dimethylase in complex with ketaconazole enzyme.

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Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 79)
Pages:
17-28
Citation:
D. Rajaraman et al., "Synthesis, Characterization and Biological Evaluation of 3'-Benzoyl-5'-(Furan-2-yl)-4'-Phenylspiro[Indoline-3,2'-Pyrrolidin]-2-One Derivatives and its Molecular Docking Studies", International Letters of Chemistry, Physics and Astronomy, Vol. 79, pp. 17-28, 2018
Online since:
August 2018
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