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Hybrid Approach for Synthesis and Antimicrobial Activity of Heterocyclic Compounds

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Abstract:

We have synthesized novel series of N-(1-(2-(1-phenyl-3-(p-tolyl)-1H-pyrazol-4-yl)-5-(pyridin-4-yl)-1,3,4-oxadiazol-3(2H)-yl)ethylidene)arylaniline and their derivatives. The structures of synthesized compounds were well characterized by spectroscopic techniques. Antimicrobial activity of the newly synthesized derivatives was evaluated against gram positive (S. aureus and S. pyogenes), gram negative bacteria (E. coli and P. aeruginosa), and strains of fungi (C. albicans, A. niger and A. clavatus). Among the screened derivatives 5c, 5f, 5i, 5l and 5t demonstrated superior antimicrobial activity against microbial strains.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 77)
Pages:
35-52
Citation:
N. C. Desai and D. V. Vaja, "Hybrid Approach for Synthesis and Antimicrobial Activity of Heterocyclic Compounds", International Letters of Chemistry, Physics and Astronomy, Vol. 77, pp. 35-52, 2018
Online since:
January 2018
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[1] N. Desai, S. Joshi, K. Jadeja, "A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents", Journal of Heterocyclic Chemistry, 2019

DOI: https://doi.org/10.1002/jhet.3821

[2] A. Fakhree, Z. Ghasemi, M. Rahimi, A. Shahrisa, "Enhanced catalytic performance of copper iodide in 1,2,3‐triazole‐imidazole hybrid synthesis, and evaluation of their anti‐cancer activities along with optical properties besides 1H‐tetrazole‐imidazole hybrids", Applied Organometallic Chemistry, 2020

DOI: https://doi.org/10.1002/aoc.5773