![Synthesis and Biological Evaluation of some Novel Pyrano[2,3-<i>d</i>]Pyrimidine Derivatives](/ILCPA.74.9/preview.gif)
Synthesis and Biological Evaluation of some Novel Pyrano[2,3-d]Pyrimidine Derivatives
Abstract:
Info:
This work is licensed under a
Creative Commons Attribution 4.0 International License
[1] L.F. Tietze, Domino reactions in organic chemistry, Wiley-VCH, Weinheim. 20 (2006) 208–330.
[2] J.K. Gallos, A.E. Koumbis, Domino Knoevenagel hetero Diels-Alder reactions of sugar derived δ, ε-unsaturated aldehydes, Arkivoc. 6 (2003) 135–144.
DOI: https://doi.org/10.3998/ark.5550190.0004.616[3] L.F. Tietze, U. Beifuss, Sequential transformations in organic chemistry: A synthetic strategy with a future, Angewandte Chemie International Edition in English. 32(2) (1993) 131–163.
DOI: https://doi.org/10.1002/anie.199301313[4] M.E. Fox, I.C. Lennon, G. Meek, A novel synthesis of 5-hydroxy-2, 2-dimethyl-10-propyl-2H-pyrano [2, 3-f] chromen-8-one, Tetrahedron Letters. 43(16) (2002) 2899–2902.
DOI: https://doi.org/10.1016/s0040-4039(02)00428-8[5] G.L. Anderson, J.L. Shim, A.D. Broom, Pyrido [2, 3-d] pyrimidines. IV. Synthetic studies leading to various oxopyrido [2, 3-d] pyrimidines, The Journal of Organic Chemistry. 41(7) (1976) 1095–1099.
DOI: https://doi.org/10.1002/chin.197630249[6] E.M. Grivsky et al., Synthesis and antitumor activity of 2, 4-diamino-6-(2, 5-dimethoxybenzyl)-5-methylpyrido [2, 3-d] pyrimidine, J. Med. Chem. 23 (1980) 327–329.
[7] D. Heber, C. Heers, U. Ravens, Positive inotropic activity of 5-amino-6-cyano-1, 3-dimethyl-1, 2, 3, 4-tetrahydropyrido [2, 3-d] pyrim idine-2, 4-dione in cardiac muscle from guinea-pig and man. Part 6: Compounds with positive inotropic activity, Die Pharmazie. 48(7) (1993).
DOI: https://doi.org/10.1002/ardp.19903230911[8] Y. Sakuma et al., Fused pyrimidine derivative, process for preparation of same and pharmaceutical preparation comprising same as active ingredient, U.S. Patent 5, 378, 700, (1995).
[9] L.R. Bennett et al., Antihypertensive activity of 6-arylpyrido [2, 3-d] pyrimidin-7-amine derivatives, J. Med. Chem. 24(4) (1981) 382–389.
[10] J. Davoll, J. Clarke, F.E. Eislager, Antimalarial substances. 26. Folate antagonists. 4. Antimalarial and antimetabolite effects of 2, 4-diamino-6-[(benzyl) amino] pyrido [2, 3-d] pyrimidines, J. Med. Chem. 15(8) (1972) 837–839.
DOI: https://doi.org/10.1021/jm00278a009[11] B. Baruah, P.J. Bhuyan, Tertiary amine effect: synthesis of some novel spirosubstituted pyrido [2, 3-d] pyrimidines, Tetrahedron Letters. 50(2) (2009) 243–245.
DOI: https://doi.org/10.1016/j.tetlet.2008.10.125[12] A.H. Shamroukh et al., Synthesis, isomerization, and antimicrobial evaluation of some pyrazolopyranotriazolopyrimidine derivatives, Archiv der Pharmazie. 340(7) (2007) 345–351.
[13] A.H. Shamroukh et al., Synthesis of pyrazolo [4', 3': 5, 6] pyrano [2, 3‐d] pyrimidine derivatives for antiviral evaluation, Archiv der Pharmazie. 340(5) (2007) 236–243.
[14] C. Musstazza et al., Synthesis of pyrazolo [1, 5-a]-, 1, 2, 4-triazolo [1, 5-a]-and imidazo [1, 2-a] pyrimidines related to zaleplon, a new drug for the treatment of insomni, J. Heterocycl. Chem. 38 (2001) 1119–1130.
[15] Y. Gao et al., Effective synthesis of 7‐amino‐6‐cyano‐5‐aryl‐5 H‐pyrano [2, 3‐d] pyrimidine‐2, 4 (1 H, 3 H)‐diones under microwave irradiation, Synthetic communications. 34(7) (2004) 1295–1299.
DOI: https://doi.org/10.1081/scc-120030318[16] I. Devi, Kumar, P.J. Bhuyan, A novel three-component one-pot synthesis of pyrano [2, 3-d] pyrimidines and pyrido [2, 3-d] pyrimidines using microwave heating in the solid state, Tetrahedron Letters. 44(45) (2003) 8307–8310.
DOI: https://doi.org/10.1016/j.tetlet.2003.09.063[17] T.S. Jin et al., A clean one-pot synthesis of 7-amino-5-aryl-6-cyano-1, 5-dihydro-2H-pyrano [2, 3-d] pyrimidine-2, 4 (3H)-diones in aqueous media under ultrasonic irradiation, J. Chem. Res. 3 (2005) 162–163.
DOI: https://doi.org/10.3184/0308234054213672[18] H.R. Safaei et al., Glycerol as a biodegradable and reusable promoting medium for the catalyst-free one-pot three component synthesis of 4H-pyrans, Green Chem. 14(6) (2012) 1696–1704.
DOI: https://doi.org/10.1039/c2gc35135h[19] Vogel's Textbook of practical organic chemistry, Fifth Edition, ELBS, Longman Scientific and Technical: England, 1989, Reprinted, (1994).
[20] National Committee for Clinical and Laboratory Standards, Method for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically Approved Standard, fourth ed. NCCLS, Villanova, Italy, Document M 100-S7. (1997) S100–S157.