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ILCPA > Volume 73 > Synthesis and Biological Evaluation of Chalcones...
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Synthesis and Biological Evaluation of Chalcones Possessing Ring Activating Groups as Potent of Anticancer Agents

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Abstract:

Some novel anticancer agents based on chalcone scaffold were synthesized with potential therapeutic application for many types of cancer. Hydroxy and methoxy substitution on aryl ring of chalcone, depending upon positions in aryl ring influence anticancer and other activities. These chalcone molecules were evaluated for their invitro cytotoxic activity against five cancer cell lines including human chronic myelogenus-leukemia K-562, human breast adenocarcinoma MCF-7, human prostate carcinoma DU-145, human lung adenocarcinoma A-549 and normal VERO cell line. Most of the compounds being active cytotoxic agents and were shown to be non-toxic to normal cells. The synthesized compounds were characterized by means of their FT-IR, MASS and 1HNMR spectral study.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 73)
Pages:
1-8
DOI:
10.18052/www.scipress.com/ILCPA.73.1
Citation:
M. M. Khanusiya and Z. M. Gadhawala, "Synthesis and Biological Evaluation of Chalcones Possessing Ring Activating Groups as Potent of Anticancer Agents", International Letters of Chemistry, Physics and Astronomy, Vol. 73, pp. 1-8, 2017
Online since:
Apr 2017
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