Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 71 > A Novel Use of 3-Methyl-2-Benzothiazolinone...
< Back to Volume

A Novel Use of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride Monohydrate for Kinetic Spectrophotometric Determination of Captopril in Pharmaceutical Formulations

Full Text PDF

Abstract:

A new, simple and sensitive kinetic spectrophotometric method has been proposed for the determination of captopril (CPT) in pharmaceutical formulations. The method is based on oxidation of 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) by ferric chloride followed by its coupling with the drug to form green-yellow colored product with absorbance maximum at 395nm. The concentration of CPT was calculated using the calibration equation for the rate data and fixed time methods. The linearity range was found to be 0.5–22.5 μg mL-1 for each method. The correlation coefficients were 0.9994 and 0.9971 for rate data and fixed time methods respectively. The proposed methods were applied successfully for the determination of CPT in pharmaceutical formulations. Statistical comparison of the results shows that there is no significant difference between the proposed and official methods.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 71)
Pages:
29-39
Citation:
M. Khateeb et al., "A Novel Use of 3-Methyl-2-Benzothiazolinone Hydrazone Hydrochloride Monohydrate for Kinetic Spectrophotometric Determination of Captopril in Pharmaceutical Formulations", International Letters of Chemistry, Physics and Astronomy, Vol. 71, pp. 29-39, 2016
Online since:
Nov 2016
Export:
Distribution:
References:

[1] L. Brunton et al., The Pharmacological Basis of Therapeutics, 10th ed, McGraw-Hill, (2001).

[2] K. Parfitt, W. Martindale, The Complete Drug Reference, The Pharmaceutical Press, London. 720 (1999) 836.

[3] D.W. Cushman et al., Design of potent competitive inhibitors of angiotensin-converting enzyme. Carboxyalkanoyl and mercaptoalkanoyl amino acids, Biochemistry. 16 (1977) 5484-5491.

[4] P.R.S. Ribeiro, L. Pezza, H.R. Pezza, A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate, Eclet. Quim. 35 (2010) 79-88.

[5] P.D. Tzanavaras et al., Reversed flow-injection manifold for the spectrophotometric determination of captopril based on its inhibitory effect on the Co(II) – 2, 2'-dipyridyl-2-pyridylhydrazone complex formation, Talanta. 57 (2002) 575-581.

[6] A.M. El-Didamony, E.A.H. Erfan, Spectrochim, Utilization of oxidation reactions for the spectrophotometric determination of captopril using brominating agents, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 75(3) (2010).

[7] N.E. Enany, F. Bela, M. Rizk, Novel Spectrophotometric method for the assay of captopril in dosage forms using 2, 6-Dichloroquinone-4-Chlorimide, Int. J. Biomed Sci. 4 (2008) 146-154.

[8] M. Skowron, W. Ciesielski, Spectrophotometric determination of methimazole, D-penicillamine, captopril, and disulfiram in pure form and drug formulations, J. Anal. Chem. 66 (2011) 714.

[9] I. Panderi, M. Parissi-Poulou, Determination of captopril and captopril-hydrochlorothiazide combination in tablets by derivative UV spectrophotometry, Int. J. Pharm. 86(2-3) (1992) 99-106.

[10] J.A.V. Prior, J.L.M. Santos, J.L.F.C. Lima, Exploiting kinetic spectrophotometric determination of captopril, an angiotensin-converting enzyme inhibitor, in a multi-pumping flow system, Anal. Chim. Acta. 600 (2007) 183-187.

[11] Y. El-Shabrawy, N. El-Enany, K. Salem, Sensitive kinetic spectrophotometric determination of captopril and ethamsylate in pharmaceutical preparations and biological fluids, Il Farmaco. 59(10) (2004) 803-808.

[12] Z. Moldovan, A Spectrophotometric method for captopril determination by using fluorescein natrium-bromine system, Rev. Roum. Chim. 57 (2012) 721-727.

[13] N. Rahman et al., A sensitive kinetic spectrophotometric method for the determination of captopril in bulk and dosage forms, Acta. Pharm. 56 (2006) 347–357.

[14] M. Jain, S.N. Shrivastava, A stability indicating assay method for captopril tablets by high performance liquid chromatography for stability studies, Anal Chem. 3 (2006) 78-83.

[15] D. Meiju, Determination of captopril in human plasma by liquid chromatography/tandem mass spectrometry, Anal Lett. 40 (2007) 3245-3255.

[16] R.J. Kok et al., Bioanalysis of captopril: two sensitive high-performance liquid chromatographic methods with pre-or postcolumn fluorescent labeling, J. Chrom. B. Biomed. Sci. Appl. 693(1) (1997) 181-189.

[17] J.A. Squella et al., Voltammetric behaviour of captopril in pharmaceutical forms, Bol. Soc. Chil. Quim. 37 (1992) 259.

[18] P. Passamont, V. Bartcci, F. Pucciarelli, Determination of Captropril using adsorptive cathodic differential pulse stripping voltammetry with the HMDE, Journal of electroanalytical chemistry and interfacial electrochemistry. 230(1) (1987) 99-108.

[19] G.K. Ziyatdinova, G.K. Budnikov, V.I. Pogorel'tsev, Determination of captopril in pharmaceutical forms by stripping voltammetry, J. Anal. Chem. 61 (2006) 798-800.

[20] S.M. Al-Ghannam, A.M. El-Brashy, B.S. Al-Farhan, Fluorimetric determination of some thiol compounds in their dosage forms, Il Farmaco. 57 (2002) 625-629.

[21] M.A. El Reis, F.M. Abou Attia, I.M.M. Kenawy, Indirect determination of captopril by AAS, J. Pharm. Biomed. Anal. 23 (2000) 249–254.

[22] A.M. Pimenta, A.N. Araújo, M.C.B.S.M. Montenegro, Sequential injection analysis of captopril based on colorimetric and potentiometric detection, Anal. Chim. Acta. 438 (2001) 31-38.

[23] Jr. E. Schmidt, W.R. Melchert, F.R.P. Rocha, Flow-injection iodimetric determination of captopril in pharmaceutical preparations, J. Braz. Chem. Soc. 20 (2009) 236-242.

[24] B. Li, Z. Zhang, M. Wu, Flow-injection chemiluminescence determination of captopril using on-line electrogenerated silver (II) as the oxidant, Microchemical Journal. 70(2) (2001) 85-91.

[25] P.D. Tzanavaras, Automated Determination of Captopril by Flow and Sequential Injection Analysis: A Review, Anal. Lett. 44 (2011) 560-576.

[26] M. A. Khalilzadeh et al., Determination of captopril in patient human urine using ferrocenemonocarboxylic acid modified carbon nanotubes paste electrode, Chin. Chem. Lett. 21 (2010) 1467-1470.

[27] S.R. Crouch et al., Kinetic determinations and some kinetic aspects of analytical chemistry, Anal. Chem. 70 (1998) 53–106.

[28] A. Espinosa-Mansilla et al., Kinetic determination of ansamicins in pharmaceutical formulations, Anal. Chim. Acta. 376 (1998) 365-375.

[29] R.A. Bartsch, S. Hunig, H. Quast, Mechanism of oxidation of 3-methyl-2-benzothiazolinone hydrazone by potassium ferricyanide in aqueous methanol, J. Am. Chem. Soc. 92 (1970) 6007–6011.

[30] A.R. Kartritzky, C.W. Rees, Comprehensive Heterocyclic Chemistry, Pergamon Press, Oxford. 7 (1984) 527.

[31] M. Kopanica et al., Kinetic Methods in Chemical Analysis, Eds., Elsevier, Amsterdam, The Netherlands, (1983).

[32] D.P. Bendito, M. Silva, Kinetic Methods in Analytical Chemistry, chapter 11, John Wiley & Sons, New York, USA, (1988).

[33] J. Rose, Advanced Physico-chemical Experiments: A Textbook of Pract. Phys. Chemistry and Calculations, Pittman, London, (1964).

[34] USP – The United States Pharmacopeia: The National Formulary. 25th ed. Rockville: The United States Pharmacopeial Convention – Twinbrook Parkway, (2007).

Show More Hide