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ILCPA > Volume 70 > Synthesis, Characterization and Antibacterial...
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Synthesis, Characterization and Antibacterial Activity of 2-Phenylsulphonamide Derivatives of Some Amino Acids

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Abstract:

The 2-phenylsulphonamide derivatives of amino acids were synthesis by simple substitution of benzenesulphonylchloride (6) with amino acids (1-5) containing pharmacological active functionalities. Structures of the synthesised compounds (7a-7e) were characterised using FT-IR, NMR (1H, 13C) and elemental analysis. The anti bacterial activities of the synthesised compounds were evaluated against gram positive bacteria: Staph and Streptococcus, gram negative bacteria: E-coli, Klebsiella, Proteus, and pseudomonas using 200 µl of 10 mg/ml and minimum inhibitory concentration (MIC) were also determined. The compounds exhibited effective anti bacterial properties though some are not more active than the standard drug ciprofloxacin.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 70)
Pages:
42-47
DOI:
10.18052/www.scipress.com/ILCPA.70.42
Citation:
C. B. C. Ikpa et al., "Synthesis, Characterization and Antibacterial Activity of 2-Phenylsulphonamide Derivatives of Some Amino Acids", International Letters of Chemistry, Physics and Astronomy, Vol. 70, pp. 42-47, 2016
Online since:
Sep 2016
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