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A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity

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Abstract:

A series of novel [1,2,3]-triazolyl substituted benzo [c] coumarins have been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts with 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl) ethanones in the presence of sodium acetate in refluxing acetic acid. The structures of the synthesized compounds have been elucidated by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the synthesized compounds have been screened for their in vitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 70)
Pages:
1-11
DOI:
10.18052/www.scipress.com/ILCPA.70.1
Citation:
N. N. Gohil et al., "A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 70, pp. 1-11, 2016
Online since:
Sep 2016
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