A series of novel [1,2,3]-triazolyl substituted benzo [c] coumarins have been synthesized by reacting various 3-coumarinoyl methyl pyridinium bromide salts with 1-(5-methyl-1-phenyl-1H-1,2,3-triazol-4-yl) ethanones in the presence of sodium acetate in refluxing acetic acid. The structures of the synthesized compounds have been elucidated by IR, 1H-NMR, 13C-NMR and Mass spectral data. All the synthesized compounds have been screened for their invitro anti-bacterial and anti-fungal activities. Some of the compounds have been found to be active against some bacterial and fungal pathogens compared to standard drugs.
International Letters of Chemistry, Physics and Astronomy (Volume 70)
N. N. Gohil et al., "A Novel and Efficient Synthesis of [1,2,3]-Triazolyl Substituted Benzo[c]Coumarins and Evaluation of their Antimicrobial Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 70, pp. 1-11, 2016