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Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues

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Abstract:

The present study is in the interest of some synthesized novel derivatives containing 4-(1,3-diphenyl-1H-pyrazol-4-yl)-N-(morpholinomethyl)-6-arylpyrimidin-2-amines pooled with different bio-active heterocycles such as pyrazole, pyrimidine and morpholine derivatives. The structures of newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR and mass spectral data. The synthesized compounds were evaluated for their in vitro antimicrobial activity against different bacterial and fungal strains using Mueller-Hinton Broth dilution method. On the basis of SAR studies, it was observed that the presence of electron withdrawing groups remarkably enhanced the antimicrobial activity of synthesized compounds.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 69)
Pages:
87-96
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.69.87
Citation:
N. C. Desai et al., "Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues", International Letters of Chemistry, Physics and Astronomy, Vol. 69, pp. 87-96, 2016
Online since:
Aug 2016
Authors:
Nisheeth C. Desai, Bonny Y. Patel, Bharti P. Dave
Keywords:
1,3-Diphenyl-1H-Pyrazole-4-Carbaldehyde, Antimicrobial Evaluation, MIC, Pyrazole, Pyrimidine
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

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