Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues

Desai, Nisheeth C.; Patel, Bonny Y.; Dave, Bharti P.

doi:10.18052/www.scipress.com/ILCPA.69.87

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Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues

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Abstract:

The present study is in the interest of some synthesized novel derivatives containing 4-(1,3-diphenyl-1H-pyrazol-4-yl)-N-(morpholinomethyl)-6-arylpyrimidin-2-amines pooled with different bio-active heterocycles such as pyrazole, pyrimidine and morpholine derivatives. The structures of newly synthesized compounds were elucidated by IR, ¹H NMR, ¹³C NMR and mass spectral data. The synthesized compounds were evaluated for their in vitro antimicrobial activity against different bacterial and fungal strains using Mueller-Hinton Broth dilution method. On the basis of SAR studies, it was observed that the presence of electron withdrawing groups remarkably enhanced the antimicrobial activity of synthesized compounds.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 69)

Pages:

87-96

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.69.87

Citation:

N. C. Desai et al., "Approach for the Synthesis of Potent Antimicrobials Containing Pyrazole, Pyrimidine and Morpholine Analogues", International Letters of Chemistry, Physics and Astronomy, Vol. 69, pp. 87-96, 2016

Online since:

August 2016

Authors:

Nisheeth C. Desai, Bonny Y. Patel, Bharti P. Dave

Keywords:

1,3-Diphenyl-1H-Pyrazole-4-Carbaldehyde, Antimicrobial Evaluation, MIC, Pyrazole, Pyrimidine

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Open Access

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Creative Commons Attribution 4.0 International License

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