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Synthesis and Nitration of 7-Hydroxy-4-Methyl Coumarin via Pechmann Condensation Using Eco-Friendly Medias

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Abstract:

A nitro coumarin derivatives has been synthesized via nitration of 7-hydroxy-4-methyl coumarin wich was synthesized via Pechmann condensation resorcinol with a β-ketoester using Amberlyst-15 as a green and efficient catalyst and by caring out the reaction of resorcinol and ethyl acetoacetate (with 1: 1 mol ratio) in the presence of 0.2 g of Amberlyst-15 at 110°C under solvent-free conditions. These nitro coumarin derivatives have biological activity and momentousness in the industrial fields. The purified products were measured the melting points and characterized by spectral methods: FT-IR, 1H-NMR , 13C-NMR.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 69)
Pages:
66-73
Citation:
F. A. H. Hussien et al., "Synthesis and Nitration of 7-Hydroxy-4-Methyl Coumarin via Pechmann Condensation Using Eco-Friendly Medias", International Letters of Chemistry, Physics and Astronomy, Vol. 69, pp. 66-73, 2016
Online since:
August 2016
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[1] M. Salem, M. Helal, M. Gouda, Y. Ammar, M. El-Gaby, S. Abbas, "An overview on synthetic strategies to coumarins", Synthetic Communications, Vol. 48, p. 1534, 2018

DOI: https://doi.org/10.1080/00397911.2018.1455873

[2] S. Rizk, G. Elsayed, M. El-Hashash, "One-pot synthesis, spectroscopic characterization and DFT study of novel 8-azacoumarin derivatives as eco-friendly insecticidal agents", Journal of the Iranian Chemical Society, 2018

DOI: https://doi.org/10.1007/s13738-018-1402-3