Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 69 > Cephradine Intercalated Mg-Al Layered Double...
< Back to Volume

Cephradine Intercalated Mg-Al Layered Double Hydroxide

Full Text PDF


Engineered advanced functional materials are promising candidates for biotechnology and biomedical science. Mg-Al layered double hydroxide (LDH), anionic or hydrotalcite-like clays consist of positively charged layers and exchangeable anions along with water molecules in the interlayer space were synthesized from homogeneous solution of MgCl2 and AlCl3 by urea induced co-precipitation method. A pharmaceutically important drug, cephradine was intercalated with synthesized LDH in alkali media (pH 10) by in-situ technique. Characterizations of the products were carried out using Attenuated Total Reflectance Infra-red (ATR-IR), Energy Dispersive X-ray (EDX) and X-ray Diffraction (XRD) spectroscopy. Scanning electron morphological images envisaged a distinct crystalline and amorphous phases of Mg-Al LDH before and after modification with cephradine. Intercalation of bioactive molecules with LDH would enhance their stability providing sustained release behavior in physiological environment.


International Letters of Chemistry, Physics and Astronomy (Volume 69)
M. Ashaduzzaman et al., "Cephradine Intercalated Mg-Al Layered Double Hydroxide", International Letters of Chemistry, Physics and Astronomy, Vol. 69, pp. 1-9, 2016
Online since:
Aug 2016

[1] F. Cavani, F. Trifiro, A. Vaccari, Hydrotalcite-like anionic clays: preparation, properties and applications, Catalysis Today. 11(1991) 173–301.

[2] S.P. Newman, W. Jones, Comparative study of some layered hydroxide salts containing exchangeable interlayer anions, Journal of Solid State Chemistry. 148(1999) 26–40.

[3] A. Vaccari, Clays and catalysis: a promising future, Applied Clay Science, 14(1999) 161–198.

[4] S.P. Newman, W. Jones, Synthesis, characterization and applications of layered double hydroxides containing organic guests, New Journal of Chemistry. 22(1998) 105–115.

[5] P. Yang, J. Yu, Z. Wang, Q. Liu, T. Wu, Urea method for the synthesis of hydrotalcites, Reac. Kinetics Catal. Lett. 83(2004) 275–282.

[6] U. Costantino, F. Marmottini, M. Nocchetti, R. Vivani, New synthetic routes to hydrotalcitelike compounds- characterization and properties of the obtained materials, Europian Journal of Inorganic Chemistry. (1998) 1434–1446.

[7] M. Ogawa, H. Kaiho, Homogeneous precipitation of uniform hydrotalcite particles, Langmuir. 18 (2002) 4240–4242.

[8] G. Mascolo, Synthesis of anionic clays by hydrothermal crystallization of amorphous precursors, Applied Clay Science. 10 (1995) 21–30.

[9] S. Aisawa, S. Takahashi, W. Ogasawara, Y. Umetsu, E. Narita, Direct intercalation of amino acids into layered double hydroxides by coprecipitation, Journal of Solid State Chemistry. 162 (2001) 52–62.

[10] S. Aisawa et al., Intercalation of nucleotides into layered double hydroxides by ion exchange, Applied Clay Science. 28 (2005) 137–145.

[11] A.V. Radha, P.V. Kamath, C. Shikuvakumara, Mechanism of the anion exchange reactions of the layered double hydroxides (LDHs) of Ca and Mg with Al, Solid State Sciences. 7(2005) 1180–1187.

[12] J.C. Dupin et al., Intercalation compounds of Mg-Al layered double hydroxides with dichlophenac: different methods of preparation and physico-chemical characterization, Applied Clay Science. 27(1) (2004) 95–106.

[13] S. Miyata, Physico-chemical properties of synthetic hydrotalcites in relation to composition, Clays and Clay Minerals. 28(1980) 50–56.

[14] A. I. Khan, D. O'Hare, Intercalation chemistry of layered double hydroxides: recent developments and applications, Journal of Materials Chemistry. 12 (2002) 3191 –3198.

[15] T. Kameda, M. Saito, Y. Umetsu, Preparation and Characterisation of Mg–Al Layered Double Hydroxides Intercalated with 2-Naphthalene Sulphonate and 2, 6-Naphthalene Disulphonate, Materials Transactions. 47(3) (2006) 923- 930.

[16] M. D. Arco et al., Mg, Al layered double hydroxides with intercalated indomethacin: Synthesis, characterization, and pharmacological study, Journal of Pharmaceutical Sciences. 93 (2004) 1649–1658.

[17] J. Tronto et al., In vitro release of citrate anions intercalated in Magnesium aluminiun layered double hydroxide, Journal of Physics and Chemistry of Solids. 65 (2004) 475–480.

[18] P. Beaudot, M.E. De Roy, J.P. Besse, Intercalation of nucleotides into layered double hydroxides by ion exchange. Journal of Solid State Chemistry. 161 (2001) 332–340.

[19] M. del Arco et al., Synthesis and characterization of layered double hydroxide (LDH) intercalated with non-steroidal anti-inflammatory drugs, Journal of Solid State Chemistry. 177 (2004) 3954–3962.

[20] V. Ambrogi, G. Fardella, G. Grandolini, L. Perioli, Intercalation compounds of hydrotalcite- like anionic clays with anti-inflammatory agents-I. Intercalation and invitro release of ibupfofen. International Journal of Pharmaceutical. 220 (2001).

[21] U. Costantino et al., Hydrotalcite-like compounds as catalysts in liquid phase organic synthesis I. Knoevenagel condensation promoted by [Ni0. 73Al0. 27(OH)2](CO3)0. 135, Journal of Molecular Catalysis A: Chemistry. 195 (2003) 245–252.

[22] S. Vial et al., Nanohybrid-layered double hydroxides/urease material: Synthesis and application to urea biosensor, Materials Science and Engineering. C26 (2006) 387–392.

[23] M. Z. Hussein, A. Yahaya, L.M. Ping, Dye-interleaved nanohybrid: Evan's Blue in the lamella of Mg-Al layered double hydroxide, Dyes and Pigments. 63 (2004) 135–140.

[24] T.J. Gish et al., Transport comparison of technical grade and starch-encapsulated atrazine, Transaction of the ASAE. 34 (1991) 1738–1744.

[25] L. P. Cardoso, R. Celis, J. Cornejo, J. B. Valim, Layered double hydroxide as support for slow release of acid herbicides, Journal of Agricultural and Food Chemistry. 54 (2006) 5968–5975.

[26] T. S. Stanimirova, G. Kirov, E. Dinolova, Mechanism of hydrotalcite regeneration, Journal of Material Science Letter. 20 (2001) 453–455.

[27] M. Meyn, K. Beneke, G. Legaly, Anionic-exchange reactions of layered double hydroxides, Inorganic Chemistry. 29(1990) 5201–5207.

[28] A. Hashim, (Edited) Advances in Nanocomposite Technology. 15 (2011) 335–360.

[29] J. B. Lambert, H. F. Shurvell, D. Lightner, R. G. Cooks, Introduction to Organic Spectroscopy, Ed., Macmillan Publishing Company, New York, USA, (1987).

[30] M. Z. Hussein, N. Hashim, A. Yahaya, Z. Zainal, Synthesis of Dichlorprop-Zn/Al-hydrotalcite Nanohybrid and its Controlled Release Property, Sains Malaysiana. 40 (2011) 887–896.

[31] C. F. Reny, Mg-Al Layered Double Hydroxide: A Potential Nanofiller and Flame-Retardant for Polyethylene, Dissertation, (2007).

[32] S. Kumar, A. Malas, C. K. Das, Layered double hydroxide modified with linseed compounds for polyurethane elastomer nanocomposites, Polimery. 57 (2012) 18–24.

Show More Hide