In this research, Phenol derivatives have been reacted with aryl halides using 5 mol% Cu(I) Complex [CuClPPh3]4 as catalyst supported on Amberlyst A21. The typical reaction has been performed between p-cresol and bromobenzene. This reaction is achieved in o-xylene as solvent. However, the catalyst complex does not dissolve in o-xylene rather it acts as heterogeneous catalyst. Therefore, it is filtrated at the end of the reaction and reused several times. Accordingly, new compounds were prepared by reacting some of bromoaryl derivatives with some Phenol derivatives. It is anticipated that the synthesized compounds have a structure NSAIDs-likes that may find their applications in the pharmaceutical industries.
International Letters of Chemistry, Physics and Astronomy (Volume 68)
A. Alkayal et al., "Synthesis and Structure of New Compounds NSAIDs-Like Using a Heterogeneous Recyclable Catalyst", International Letters of Chemistry, Physics and Astronomy, Vol. 68, pp. 82-88, 2016