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Optimized Synthesis of Novel Pyrazole Based Thiazole Derivatives and their Antimicrobial Evaluation

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Abstract:

A series of nitro pyrazole based thiazole derivatives compounds were synthesized by using solid base catalyst. The process was further optimized by setting up the solvent and catalyst ratio. The structures of these compounds were elucidated by spectral (IR, 1H NMR, 13C NMR, mass spectra) analysis. Synthesized compounds were screened for their in vitro antibacterial activity against the representative panel of Gram-positive (Staphylococcus aureus, Streptococcus pyogenes) and Gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria. These compounds were tested for their inhibitory action against strains of fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus).

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 66)
Pages:
109-118
DOI:
10.18052/www.scipress.com/ILCPA.66.109
Citation:
N. C. Desai and M. J. Bhatt, "Optimized Synthesis of Novel Pyrazole Based Thiazole Derivatives and their Antimicrobial Evaluation", International Letters of Chemistry, Physics and Astronomy, Vol. 66, pp. 109-118, 2016
Online since:
May 2016
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