Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives

Kansagara, N.N.; Dangar, V.R.; Shah, V.R.

doi:10.18052/www.scipress.com/ILCPA.64.89

ILCPA > ILCPA Volume 64 > Synthesis, Characterization and Antimicrobial...

< Back to Volume

Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives

Full Text PDF

Abstract:

Schiff’s bases are obtained on heating an aldehydes with aromatic amine in presence of glacial acetic acid. These are the compounds containing characteristic –HC=N– group. Aryl amino methyl derivatives of heterocyclic compounds to synthesize by selective reduction of schiff’s bases (imine group) with sodiumborohydride in controlled experimental condition. Schiff’s base of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanimines & Aryl amines of N-Aryl-1-[6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridin-3-yl]methanamines were prepared. Their chemical structures were confirmed by means of IR, NMR, Mass data and by elemental analysis. All of the synthesized compounds were tested for their antibacterial and antifungal activity.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 64)

Pages:

89-94

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.64.89

Citation:

N.N. Kansagara et al., "Synthesis, Characterization and Antimicrobial Evaluation of Schiff’s Base and Aryl Aminomethyl Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 64, pp. 89-94, 2016

Online since:

February 2016

Authors:

N.N. Kansagara, V.R. Dangar, V.R. Shah

Keywords:

Antimicrobial Activities, Aryl Amino Methyl Derivatives, Schiff’s Bases

Export:

RIS, BibTeX, Text

Distribution:

Open Access

This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] Das, Arima, Lien, Eric J. Trousdale, Melvin D.; Chin. Pharm. J. (Taipet) 49 (2), 89-102 (Eng. ) (1997) ; Chem. Abstr., 128 (18), 217259n (1998).

[2] Ergenc, Nedime, Uinsoy, Nuray, Capangultate, Soruis, Aulten O tuk, Kiraz, Mnammer; Arch. Pharm. 329 (8-9), 427-430 (1996); Chem. Abstr., 126, 1, 8031b (1997).

[3] Pascal Rathelst, Nadine Azos, Hussain El-Kashef, Forence Delwasi; Eur. J. Med. Chem., 57, 671-679 (2002).

[4] Pawar R. P., Anduskary N. M., Vibhute V. B.; J. Indian Chem. Soc., 76(5), 271-72 (Eng. ) (1999); Chem. Abstr., 131, 677, 271829y (1999).

[5] Cascaval Alexandru, Stocia, Gheorghe-Zaharia, Berdan, Ioan ; Rom. RO, 106, 403 (Cl. CO7D 231/04) (1993), Appl. 143, 707, 15, (1990); Chem. Abstr., 129, 2, 491, 16120g (1998).

[6] Adnan A. Bekhil, Heshan T. V. Fahwy, Azzaim Baraka et. al.; Eur. J. Med. Chem., 38, 27-56 (2003).

[7] Wang, Yangang, Ye, Wenfa, Yang Jun., Lou, Aihong; Wuhan Daxue Xuebao, Ziran; Kexueban; Chem. Abstr., 125 (13), 167488b (1996).

[8] Hearn M.J. and Cynamon M.H.; JAC., 53, 185-191 (2004).

[9] G. H. Merriman, L. Ma, P. Shum, D. McGarry, F. Volz, J. S. Sabol, A. Gross, Z. Zhao, D. Rampe, L. Wang, F. Wirtz-Brugger, B. A. Harris, D. Macdonald; Bioorg. Med. Chem. Lett., 15, 435-438 (2005).

[10] D. J. Parks, L. V. LaFrance, R. R. Calvo, K. L. Milkiewicz, V. Gupta, J. Lattanze, K. Ramachandren, T. E. Carver, E. C. Petrella, M. D. Cummings, D. Maguire, B. L. Grasberger, T. Lu; Bioorg. Med. Chem. Lett., 15, 765-770 (2005).

[11] T. Guo, Y. Shao, G. Qian, L. L . Rokosz, T. M. Stauffer, R. C. Hunter, S. D. Babu, H. Gu, D. W. Hobbs; Bioorg. Med. Chem. Lett., 15, 3696-3700 (2005).

[12] W. Guba, W. Neidhart, M. Nettekoven; Bioorg. Med. Chem. Lett., 15, 1599-1603 (2005).

[13] C. W. Lindsley, Z. Zhao, W. H. Leister, R. G. Robinson, S. F. Barnett, D. Defeo-Jones, R. E. Jones, G. D. Hartman, J. R. Huff, H. E. Huber, M. E. Duggan; Bioorg. Med. Chem. Lett., 15, 761-764 (2005).

[14] A. L. Barry; The antimicrobial susceptibility test: Principle and practices, edited by llluslea & Febiger, (Philadelphia), USA, 180; Biol. Abstr., 1977, 64, 25183.

[15] Panda J. Srinivas S. V., Rao M. E.; J. Indian Chem. Soc., 79(9), 770-1 (2002); Chem. Abstr., 138, 153499n (2003).

Show More Hide

Cited By:

This article has no citations.