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International Letters of Chemistry, Physics and Astronomy
Volume 63
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Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives

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Abstract:

In this present work base catalyzed method used for formation of Chalcone of (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) reacted with derivatives of S-benzo [d] thiol-2yl-2-chloroethanethioate (Ia-f) resulted in formation of corresponding derivatives of (E)-S-benzo [d] thiazol-2-yl 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (IIIa-f) was confirmed by spectral characterization such as IR, 1H NMR, LC-MS and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel Gram-positive and Gram-negative bacteria as well as fungi.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 63)
Pages:
83-89
DOI:
10.18052/www.scipress.com/ILCPA.63.83
Citation:
F. Bhabhor et al., "Synthesis and Biologically Important of 2-Mercaptobenthiazole (MBT)-Clubbed Chalcone Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 63, pp. 83-89, 2016
Online since:
Jan 2016
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