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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 61

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Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity

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Thiazolidin-4-one is a versatile lead molecule for designing potential bioactive agents. An expeditious method for preparation of 4-thiazolidinones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiff’s base) to 4-thiazolidinone through an intermediate of THF mercapto acetic acid with anhydrous zinc chloride is important synthetic method for preparation of 4-thiazolidinone. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compounds were screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa was determined by disc diffusion technique. All the synthesized compounds exhibited promising antimicrobial activity against the studied set of microorganisms.


International Letters of Chemistry, Physics and Astronomy (Volume 61)
K. A. Parmar and S. N. Parajapati, "Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 61, pp. 84-93, 2015
Online since:
November 2015

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