Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 61

Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 61 > Formation and Biological Evaluation of...
< Back to Volume

Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity

Full Text PDF

Abstract:

Thiazolidin-4-one is a versatile lead molecule for designing potential bioactive agents. An expeditious method for preparation of 4-thiazolidinones 7(a-h) are an important class of heterocycles, having potential biological importance due to their unique features. The process of convert of imine (Schiff’s base) to 4-thiazolidinone through an intermediate of THF mercapto acetic acid with anhydrous zinc chloride is important synthetic method for preparation of 4-thiazolidinone. The structures of the synthesized compounds were confirmed by IR, 1H-NMR, 13C NMR and Mass spectral studies. The compounds were screened for their antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Esherichia coli and Pseudomonas aeruginosa was determined by disc diffusion technique. All the synthesized compounds exhibited promising antimicrobial activity against the studied set of microorganisms.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 61)
Pages:
84-93
Citation:
K. A. Parmar and S. N. Parajapati, "Formation and Biological Evaluation of 4-Thiazolidinone Derivatives for their Pharmacological Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 61, pp. 84-93, 2015
Online since:
Nov 2015
Export:
Distribution:
References:

[1] C. Frances Brown, 4-Thiazolidinones. Chemical Reviews 196 61 (5) 463–521.

[2] A.K. Jain, A. Vaidya, V. Ravichandran, S.K. Kashaw, Recent developments and biological activities of thiazolidinone derivatives: A review. Bioorganic & Medicinal Chemistry, 20 (2012) 11 3378–3395.

DOI: https://doi.org/10.1016/j.bmc.2012.03.069

[3] S.S. Syed, T.R. Radhakrishnan. Studies on biologically active heterocycles. Synthesis and antibacterial activity of some 2, 5-disubstituted-1, 3, 4-oxadiazole, 1, 3, 4- thiadiazole, 1, 2, 4-triazole and 4-thiazolidinones. Indian Journal of Heterocyclic Chemistry, 5 (1995).

[4] B.S. Vashi, D.S. Mehta, V.H. Shah, Synthesis and biological activity of 4-thiazolidinones, 2- azetidinones, 4-imidazolinone derivatives having thymol moiety. Indian Journal of Chemistry, 34B (1995) 802-808.

DOI: https://doi.org/10.1002/chin.199547230

[5] A.H. Bhatt, K.A. Parikh, A.R. Parikh, Synthesis of some thiazolidinones and 5-oxoimidazolines as biologically potent agents. Indian Journal of Chemistry, 38(B) (1999) 628-631.

[6] V.J. Sattigeri, A. Soni, S. Singhal, S. Khan, M. Pandya, Synthesis and antimicrobial activity of novel thiazolidinones. Arkivoc, 2 (2005) 46-59.

[7] M. Amir, A. Faizul. Synthesis and biological evaluation of some 4-thiazolidinones. Indian Journal of Heterocyclic Chemistry, 14 (2004) 119-122.

[8] R.P. Singh, D.V. Singh, C.R. Singh, S.P. Tripathi, S. Singh, Synthesis and antifungal activity of 2-azetidinones, 4-thiazolidinones and 5-imidazolidinones incorporating benzthiazole moiety. Journal of Chemical and Pharmaceutical Research, 4, 4 (2012).

[9] A.V. Dobaria, J.R. Patel, H.H. Parekh, Thiazolidinones bearing chloro quinolone nucleus as potential antimicrobial agents. Indian Journal of heterocyclic chemistry. 11 (2001) 115.

[10] A.K. Solonkee, I. Thakor, J. Patel, S. Lad, Synthesis and Biological assay of some new 2, 3-Diaryl-5-methyl-4-thiazolidones. Oriental J. chemistry, 20 1 (2004) 127.

[11] P. Mishra, K.P. Namdeo, S.K. Jain, S. Jain, synthesis and Antimicrobial Activity of 4-thiazolidinone. Asian J. chem, 11 1 (1991) 55.

[12] N.J. Gaikward, P. Gautam, Mannich reaction products of 5-Benzylidine-2-Thioxo-4-thiazolidinone as hypoglycemic agents, Indian J. Heterocyclic chem., 2002; 12: 181-182.

[13] D.J. Kaneria, N.J. Data, R.C. Khunt, N.H. Paresh, Synthesis and pharmacological activity of some new 4-thiazolidinone derivatives. Indian J. Heterocyclic chem, 12 (2003) 277.

[14] N. Rama Rao, B. Ramu, C. Gopinath, Synthesis and charectarisation of some biological thiazolidene. Asian Journal of chemistry, 1 (2004) 531.

[15] D.S. Nair, A.C. Shah, Synthesis of 5-thiazolidinone derivatives of (R) and (S) -2-aminobutanols. Indian Journal of heterocyclic chemistry, 16 (2007) 231.

[16] C.D. Diulatbad, G.G. Bhat, Synthesis and antimicrobial studies of 4-Thiazolidinone derivatives from 2-Bromohexanoic acid (part II). Indian Journal of heterocyclic chemistry, 9 (1999) 157.

[17] Giri, M.H. Khan, Synthesis and antifungal activity of some 3-[5'-aryl-3'-Mercapto- 1', 2', 4'-triazol-4-yl]-4-Thiazolidinones. Asian J. chem, 4 4 (1992) 812.

Show More Hide