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International Letters of Chemistry, Physics and Astronomy
Volume 61

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Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage

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Abstract:

In this article, we have described to design and synthesized a series of substituted chalcone based 1,3,4-oxadiazole derivatives. Titled compounds (E)-S-(-5-phenyl-1,3,4-oxadiazol-2-yl) 2-(4-(3-(5-methyl-3oxo-2(p-tolyl)-2,3-dihydro-1H-pyrazol-4-yl)-3-oxoprop-1-en-1-yl) phenoxy) etanethioate (III1-6) were synthesized using of derivatives of S-(-5-phenyl-1,3,4 oxadiazole-2-yl)2-chloroethaethioate (I1-6) were reacted with (E)-4-(3-(4-hydroxyphenyl) acryloyl)-5-methyl-2(p-tolyl)-1H-pyrazol-3(2H)-one (II) in presence of K2CO3 in DMF as a solvent. The synthesized compounds were evaluated for their antimicrobial activity. The newly synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, and LC-MS) Methods.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 61)
Pages:
77-83
DOI:
10.18052/www.scipress.com/ILCPA.61.77
Citation:
H. H. Variya et al., "Synthesis and Characterization of Biologically Potent Chalcone Bearing 1,3,4-Oxadiazole Linkage", International Letters of Chemistry, Physics and Astronomy, Vol. 61, pp. 77-83, 2015
Online since:
Nov 2015
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