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International Letters of Chemistry, Physics and Astronomy
Volume 59

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Potentiometric Sensors for the Determination of Valdecoxib in Pharmaceutical Preparation

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Abstract:

Valdecoxib (VALD) selective electrodes based on VALD-5,6-diamino-2-thiouracil hydrochloride (DTUH) (VALD-DTUH) ion pair in PVC matrix membrane were constructed. The plasticizers used were dibutylphthalate (DBP) (Electrode B) tri-n-butylphosphate (TBP) (electrode C), or dioctylphthalate (DOP) (electrode) A. The electrodes gave the linear range between 6.0×10−6-17.9×10−3, 2.5×10−5–8.3×10−3M, M and 2.5×10−6–2.0×10−2M respectively. The slopes for linear range ranged from 39.29 to 58.76mV/decade with correlation coefficients lying between 0.997, 0.989 and 0.999 respectively. The best detection limit was 1.50×10−6M for the electrode based on DOP. Selectivity coefficients of VALD related to a number of interfering cation and some organic compounds and excipients were studied using matched potential method (MPM(, and there were negligible interference caused by most of the investigated species. The pH and life time of the electrodes were also studied. The direct determination of VALD shows an average recovery of (100.08-100.61 and 99.75-101.00)% and a mean relative standard deviation of (2.70-0.61 and 2.39-0.56)% for sensor A and B respectively. The results obtained by determination of VALD in tablets using the proposed sensors which comparable favorably with those obtained by spectrophotometric method. Validation of the method shows the suitability of the electrodes for the determination of VALD in pharmaceutical formulation.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 59)
Pages:
93-105
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.59.93
Citation:
S. F. Rassi "Potentiometric Sensors for the Determination of Valdecoxib in Pharmaceutical Preparation", International Letters of Chemistry, Physics and Astronomy, Vol. 59, pp. 93-105, 2015
Online since:
Sep 2015
Authors:
Salwa Fares Rassi
Keywords:
5,6-Diamino-2-Thiouracil Hydrochloride, Selective Electrode, Valdecoxib
Export:
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Distribution:
Open Access

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References:

[1] Talley J. J, Brown D. L, Carter J. S, Graneto M. J, Koboldt C. M, Masferrer J. L, Perkins W. E, Rogers R. S, Shaffer A. F, Zhang Y. Y, Zweifel B. S, Seibert K., J Med Chem. 43(2000) 775.

DOI: https://doi.org/10.1021/jm990577v

[2] Gotta A W., Curr Opin Invest Drugs. 3(2002) 240.

[3] Makarowski W, Zhao W W, Bevirt T, Recker D P., Osteo-arthr Cartil. 10 (2002) 290.

[4] Fricke J, Varkalis J, Zwillich S, Adler R, Forester E., Recker D P, Verburg K M., Am J Ther. 9 (2002) 89.

[5] Kivitz A, Eisen G, Zhao W W, Bevirt T., Recker D P., J Fam Pract. 51 (2002) 530.

[6] Daniels S E, Talwalker S, Torri S, Snabes M C, Recker D P, Verburg K M., Obstet Gynecol. 100 (2002) 350.

[7] Yang J J, Zhang D C, Bible B, Karim A, Findlay J A W., Drug Metab Dispos. 30 (2002) 1013.

[8] Karim A, Laurent A, Slater M E, Kuss M E, Qian J, Crosby-Sessoms S L., Hubbard R C.,. J Clin Pharmacol. 41 (2001) 1111.

[9] Ibrahim A, Park S, Feldman J, Karim A, Kharasch E D., Anesthesiol-ogy. 96 (2002) 88.

[10] Sivasubramanian L, Devarajan L., Internat J Chem Tech Res. 1 (2009) 96.

[11] Gandhimathi M, Ravi T K, Shukla N, Sowmiya G., Indian J Pharm Sci. 69 (2007) 145.

[12] Ravi T K, Gandhimathi M, Suganthi A, Sarovar S., J Separation Sci. 29 (2006) 1647.

[13] Sérgio L D, Marcio F, Nogueira R D, Bizogne S R, Bernardi R M., J liquid chromatogr related technol. 30 (2007) 17.

[14] Keshetty S, Venisetty R K, Molmoori V, Ciddi V., Die Pharmazie. 61 (2006) 242.

[15] Subramanian G, Faisal M B V, Ranjith Kumar A, Udupa N., Indian J Pharm Sci. 68 (2006) 391.

[16] Zecevic M, Savic G, Zivanovic L., Anal. Lett. 39 (2006) 1875.

[17] Pavan Kumar V V, Vinu M C, Ramani A V, Mullangi R, Srinivas N R., Biomed. Chromatogr. 20 (2006) 125.

[18] Ramaa C S, Deshpande D K, Shirode A R, Wamorkar V V, Kakad A B, Kadam. V J., Indian J Pharm Sci. 68 (2006) 514.

DOI: https://doi.org/10.4103/0250-474x.27832

[19] Werner U, Werner D, Hinz B, Lambrecht C, Brune K., Biomed. Chromatogr. 19 (2005) 113.

[20] Suganthi A, Sivakumar H B, Shrikumar S, Gandhimathi M, Gopal R M, Ravi T K., Indian J Pharm Sci. 67 (2005) 757.

[21] Ramakrishna N V S, Vishwottam K N, Wishu S, Koteshwara M. J Chromatogr B Anal Technol Biomed Life Sci. 802 (2004) 271.

[22] Sankar A S K, Anandakumar K, Nagavalli D, Senthil P M, Vetrichelvan T, Nithyanandham. K., Indian J Pharm. Sci. 69 (2007) 132.

DOI: https://doi.org/10.4103/0250-474x.32128

[23] Sane R T, Menon S, Deshpande A Y, Jain A., Chromatographia. 61 (2005) 137.

[24] Suganthi A, Sivakumar H B, Vijayakumar S C, Ravimathi P, Ravi T K., Indian J Pharm. Sci. 68 (2006) 373.

DOI: https://doi.org/10.4103/0250-474x.26685

[25] Devarajan L, Sivasubramanian L., Indian J Pharm Sci. 68 (2006) 240.

[26] Aditya. N, Arora R K, Tiwari M., Indian J Pharm Sci. 68 (2006) 370.

[27] Nagulwar V, Tajne M R, Upadhaye K, Bakhle S, Deshpande S, Wadetwar R., Indian J Pharm Sci. 67 (2005) 624.

[28] Sutariya V B, Mashru R, Sankalia M G., Parikh P., Indian J Pharm. Sci. 66(2004), 360.

[29] Goudaa A A, El-Sayedb M I K, Aminc A S, El Sheikh R., Arabian Journal of Chemistry. 6 (2013) 145.

[30] Craggs A, Moody G J, Thomas J D R., J Chem Edu. 51 (1974) 541.

[31] Umezawa Y, Hlmann Ph B, Umezawa K, Tohda K, Amemiya Sh., Pure ApplChem. 72 (2000) 1851.

[32] Umezawa Y, Umezawa K, Sato H., Pure Appl Chem. 67 (1995) 507.

[33] Peter G, Hayes J M, Hieftje G M., Saunders, Philadelphia, USA. (1974).

[34] Baumann E., Anal Chim Acta. 42 (1968) 127.

[35] Issa Y M, Hassouna M M, Abdel-Gawad F M, Hussien E M., J Pharm Biomed Anal. 23 (2000) 493.

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