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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 59

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Synthesis, Hammett Spectral Correlations and Antimicrobial Activities of (E)-1-Benzylidene-2-(4-Chlorophenyl)Hydrazines

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In the present study, a series of nine number of (E)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been synthesized by condensation reaction of meta and para substituted benzaldehydes with 4-chlorophenylhydrazine using acetic acid catalyst. They are characterized by their physical constants, UV (200-450 nm), Infra-Red (KBr, 4000-400 cm−1) and NMR (1H and 13C) spectral data. The observed UV, IR and NMR spectral data have been correlated with Hammett substituent constants and Swain-Lupton’s F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis the effects of substituents on the spectral data have been discussed. The antimicrobial activities of all the synthesized (E)-1-benzylidene-2-(4-chlorophenyl) hydrazine compounds have been studied using Bauer–Kirby method.


International Letters of Chemistry, Physics and Astronomy (Volume 59)
M. Rajarajan et al., "Synthesis, Hammett Spectral Correlations and Antimicrobial Activities of (E)-1-Benzylidene-2-(4-Chlorophenyl)Hydrazines", International Letters of Chemistry, Physics and Astronomy, Vol. 59, pp. 147-159, 2015
Online since:
September 2015

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