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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 57

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Microwave Irradiated and Conventional Syntheses of Halogenated Symmetric Double Schiff Bases, their Spectral and Microbial Study

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The aim of the present work was to discover various synthetic route of biological active halogenated symmetric double Schiff bases of 1,1’-bis (4-aminophenyl) cyclohexane, their spectral and microbial study. Symmetric double Schiff base ligands of halogenated benzaldehyde and 1,1’-bis (4-aminophenyl) cyclohexane were synthesized by conventional and green chemistry approach. The purity of Schiff bases was checked by Thin Layer Chromatography (TLC). The structures of these ligands were elucidated by UV, FTIR, 1HNMR and MS; and assayed for their antibacterial activity against Escherichia coli (E. coli), Bacillus megaterium (B.mega), Proteus vulgaris (P. vulgaris, Staphylococcus aureus (S. aureus) and Aspergillus niger (A. niger)The minimum inhibition concentrations (MIC) of the compounds were studied by cup plate method. Schiff bases revealed moderate antimicrobial activity and good antifungal activity against chosen standard drugs and microorganisms.


International Letters of Chemistry, Physics and Astronomy (Volume 57)
B. J. Gangani and P. H. Parsania, "Microwave Irradiated and Conventional Syntheses of Halogenated Symmetric Double Schiff Bases, their Spectral and Microbial Study", International Letters of Chemistry, Physics and Astronomy, Vol. 57, pp. 36-44, 2015
Online since:
August 2015

S. Patai The chemistry of the carbon-nitrogen double bond. (John-Wiley and Sons. Ltd. London (1970).

D. N. Dhar, C. N. Taploo, J Sci. Ind. Res., 41(8) (1982) 501-506.

R.W. Layer, Chem Rev., 63 (1963) 487-507.

A. P. Mishra, M. Khare, S. K. Gautam, Synth. React Inorg. Met-Org Chem., 32(2002)14851500.

C . Bi, Y. Fan, Synth. React Inorg and Met-Org Chem. 34 (2004) 687-695.

S. Matsunaga, M. Shibasaki, Chem. Commun. 50(2014) 1044-1057.

A. Prakash, D. Adhikari, Int. J. Chem. Tech. Research. 3(4) (2011) 1891-1896.

S. H. Abdel-Hafez, Phosphorus, sulfur, and silicon. 178(2003) 2563-2579.

N.B. Patel, J.C. Patel, Arabian J Chem. 4 (2011) 403-411.

P. Panneerselvam, B. A. Rather, D. R. Reddy, N. R. Kumar, Euro. J. Med. Chem. 44, 23282333(2009).

K. D. Patel, B. D. Mistry, K. R. Desai, J. Ind. Chem. Soc., 81(2004) 783-785.

M. M. Kamel, H. L. Ali, M. M. Anawar, N. A. Mohamed, A. M. Soliman, Euro. J. Med. Chem. 45 (2010)572-580.

V. E. Kuzmin, V. P. Lozitsky, G. L. Kamalov, R. N. Lozitskaya, A. I. Zheltvay, A. S. Fedtchouk, D. N. Kryzhanovsky, Acta Biochimica, Polonica, 47(2000)867-875.

V. P. Lozitsky, V. E. Kuzmin, A. G. Artemenko, R. N. Lozytska, A. S. Fedtchouk., E. N. Muratov, A. K. Mescheriakov, SAR and QSAR in Environmental Research, 16(2005) 219-230.

A. M. Mohindru, J. M. Fisher, M. Rabinovitz, Nature, 303(1983) 64-65.

R. Tundor, N. Maria, P. Simona, P. Elena, P. Donald, G. Aurelina, Euro. J. Med. Chem., 45(2) (2010)774-781.

A.T. Shinde, S.B. Zangade, S.B. Chavan, Y.B. Vibhute Am. J. Pharmtech. Res., 2(2011)43-48.

A. B. Begum, N.D. Rekha, B. C Vasanthakumar, V. L. Ranganatha, S. A. Khanum, Bioorg. Med. Chem. Lett. DOI 10. 1016/ j. bmcl. 2014. 05. 046.

S. Mondal, M. Nayak, H. Sparkes, J. Howar, S. Mohanta, J. Coord. Chem., 67(2014)72-80.

W. Qin, S. Long, M. Panunzio , S. Biondi, Molecules. 18(2013) 12264-12289.

R. K. Jain, A. P. Mishra, J. Serb. Chem. Soc., 77 (8) (2012)1013-1029.

O. O. Ajani, C. A. Obafemi, C. O. Ikpo1, K. O. Ajanaku, K. O. Ogunniran, O. O. James, Int. J. Physical. Sci., 4 (4) (2009) 156-164.

B. J. Gangani, P. H. Parsania, Spectroscopy Letters 40(2007) 97-112.

A. L. Bary, The antimicrobial susceptibility test, principle and practice, 180 -193(Philadelphia, 1976).

M. Yadav, N. Mishra, N. Sharma, S. Chandra, D. Kumar, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 132(2014) 733-742.

N. K. Jain, Progress in control Release Drug delivery system. 470-491(CBS Publication, New Delhi, 2004).

J. B. Schwartz, Optimization techniques in pharmaceutical formulation and processing in Banker, 4 th Ed., 803-828(Modern pharmaceutics, Marcel Dekker, New York, 2000).

J. Panda, V. J. Patro, B. M. Sahoo, J. Mishra, J. of Nanomaterials, Article ID 549502 (2013).

A. Esteves-Souze, K. Pissinate, M. Grac, N. Noem, F. Grynberg, A. Echevarria, Bio. Org. Med. Chem. 14(2006) 492-499.

B. Shafaatian, A. Soleymanpour, N. K. Oskouei, B. Notash, S.A. Rezvani, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 128(2014) 363-369.

C. A. Sandorfy, J. W. Lewis, Can. J. Chem. 60(13) (1982)1727-1737.

M. Yildiz, Z. Kilic, T. Hokelek, Mol. Struct. 441(1998) 1-10.

B. Bonish, J. Am. Chem. Soc. 90(1968) 627-632.

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[1] B. Gangani, P. Parsania, "Effect of Substitutions on Thermal Behavior of Symmetric Doubleschiff Bases of 1,1’-Bis(4-Amino Phenyl)Cyclohexane", International Letters of Chemistry, Physics and Astronomy, Vol. 63, p. 145, 2016