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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 57
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Synthesis and Assessment of Substituent Effect on (<i>E</i>)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds
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Synthesis and Assessment of Substituent Effect on (E)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds

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Abstract:

In the present investigation, a series of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds were synthesized by condensation reaction of 4-fluoro-3-methyl acetophenone with substituted benzaldehydes in the presence of alkali. The yields of synthesized compounds are more than 80%. The structures of all the synthesized compounds were confirmed by their physical constants, UV, IR and NMR spectral data. All the observed spectral data of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses. From the results of statistical analysis the effects of substituents have been discussed.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 57)
Pages:
145-155
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.57.145
Citation:
S. Balaji et al., "Synthesis and Assessment of Substituent Effect on (E)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds", International Letters of Chemistry, Physics and Astronomy, Vol. 57, pp. 145-155, 2015
Online since:
August 2015
Authors:
S. Balaji, M. Rajarajan, R. Vijayakumar, V. Manikandan, R. Senbagam, Ganesan Vanangamudi, G. Thirunarayanan
Keywords:
4-Fluoro-3-Methyl Acetophenone, IR, NMR Spectra, Spectral Correlation Analysis, Substituent Effect, Synthesis, UV
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Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

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Cited By:

[1] R. Senbagam, R. Vijayakumar, M. Rajarajan, S. Balaji, V. Manikandan, G. Vanangamudi, G. Thirunarayanan, "Synthesis, assessment of substituent effect and antimicrobial activities of (4E)-4-(benzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one compounds", Karbala International Journal of Modern Science, Vol. 2, p. 56, 2016

DOI: https://doi.org/10.1016/j.kijoms.2016.01.004