In the present investigation, a series of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds were synthesized by condensation reaction of 4-fluoro-3-methyl acetophenone with substituted benzaldehydes in the presence of alkali. The yields of synthesized compounds are more than 80%. The structures of all the synthesized compounds were confirmed by their physical constants, UV, IR and NMR spectral data. All the observed spectral data of substituted (E)-1-(4-fluoro-3-methylphenyl)-3-phenylprop-2-en-1-one compounds have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses. From the results of statistical analysis the effects of substituents have been discussed.
International Letters of Chemistry, Physics and Astronomy (Volume 57)
S. Balaji et al., "Synthesis and Assessment of Substituent Effect on (E)-1-(4-Fluoro-3-Methylphenyl)-3-Phenylprop-2-en-1-One Compounds", International Letters of Chemistry, Physics and Astronomy, Vol. 57, pp. 145-155, 2015