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International Letters of Chemistry, Physics and Astronomy
Volume 57

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An Efficient Synthesis and Antimicrobial Evaluation of some New Pyrazoline, Pyrimidine and Benzodiazepine Derivatives Bearing 1,3,5-Triazine Core

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Abstract:

In our present investigation a new class of diverse sets of acetyl pyrazolines (6a-e), amino pyrimidines (7a-e) and 1,5-benzodiazepines (8a-e) bearing 1,3,5-triazine core were synthesised from chalcones (5a-e). Treatment of chalcone with hydrazine hydrate, guanidine hydrochloride and o-phenylenediamine afforded the corresponding acetyl pyrazoline, amino pyrimidine and 1,5-benzodiazepine derivatives respectively. The structures of all the newly synthesised compounds were assigned on the basis of FTIR, 1H NMR, 13C NMR, mass spectral data as well as elemental analysis. In vitro antimicrobial proficiency of the title compounds were assessed against selected pathogens S. aureus MTCC 96, S. pyogeneus MTCC 442, E. coli MTCC 443 and P. aeruginosa MTCC 1688 bacteria for antibacterial activities as well as antifungal activities against C. albicans MTCC 227, A. niger MTCC 282 and A. clavatus MTCC 1323 were used. The minimum inhibitory concentration (MIC) was determined by broth dilution method and recorded at the lowest concentration inhibiting growth of the organism. Among the synthesised compounds 6b, 6c, 7b, 8b, 8d and 8e exhibited excellent antimicrobial activity and said to be the most proficient members of the series.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 57)
Pages:
13-24
Citation:
A. Solankee and R. Tailor, "An Efficient Synthesis and Antimicrobial Evaluation of some New Pyrazoline, Pyrimidine and Benzodiazepine Derivatives Bearing 1,3,5-Triazine Core", International Letters of Chemistry, Physics and Astronomy, Vol. 57, pp. 13-24, 2015
Online since:
Aug 2015
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References:

B. L. Caminato, D. Milena, M. M. Helena, Brazilian Journal of Microbiology 45 (2014) 1-5.

S. M. Khersonsky, D. -W. Jung, T. -W. Kang, D. P. Walsh, H. -S. Moon, H. Jo, E. M. Jacobson, V. Shetty, T. A. Neubert, Y. -T Chang, Journal of American Chemical Society (2003) 125, 11804-11805.

B. Zacharie, S. D. Abbott, J. F. Bienvenu, A. D. Cameron, J. Cloutier, J. S. Duceppe, A. Ezzitouni, D. Fortin, K. Houde, C. Lauzon, N. Moreau, V. Perron, N. Wilb, M. Asselin, A. Doucet, M. E. Fafard, D. Gaudreau, B. Grouix, F. Bournet, N. Amant, L. Gagnon and C. L. Penney, Journal of Medicinal Chemistry 53 (2010).

X. Fu, J. Feng, Z. Dong, L. Lin, X. Liu and X. feng, European Journal of Organic Chemistry 2011 (2011) 5233-5236.

V. H. S. Jois, B. Kalluraya, K. S. Girisha, Journal of Serbian Chemical Society 79 (2014) 1469-1475.

S. Raghavan and K. Anuradha, Tetrahedron Letters 43 (2002) 5181-5183.

H. B. Lad, R. R. Giri, D. I. Brahmbhatt, Chinese Chemical Letters 24 (2013) 227-229.

N. M. M. Hamada and E. M. Sharshira, Molecules 16 (2011) 2304-2312.

S. Bano, K. Javed, S. ahmad, I. G. Rathish, S. Singh, M. S. Alam, European Journal of Medicinal Chemistry 46 (2011) 5763-5768.

C. Congiu, V. Onnis, L. Vesci, M. Castorina, C. Pisano, Bioorganic & Medicinal Chemistry 18 (2010) 6238-6248.

F. Manna, F. Chimenti, R. Fioravanti, A. Bolasco, D. Secci, P. Chimenti, C. Ferlini and G. Scambia, Bioorganic & Medicinal Chemistry 15 (2005) 4632-4635.

A. Solankee and R. Tailor, International Letters of Chemistry, Physics and Astronomy 8 (2015) 109-119.

M. Sharma, V. Chaturvedi, Y. K. Manju, S. Bhatnagar, K. Srivastava, S. K. Puri, P. M. S. Chauhan, European Journal of Medicinal Chemistry 44 (2009) 2081-(2091).

(a) A. Solankee, A. Kapadia, Anaciric, M. Sokovic, I. Doytchinova, A. Geronikaki, European Journal of Medicinal Chemistry 45 (2010).

R. P. Yejella and S. R. Atla, Chemical and Pharmaceutical Bulletin 59 (2011) 1079-1082.

J. Majeed and M. Shaharyar, Journal of Enzyme Inhibition and Medicinal Chemistry 26 (2011) 819-826.

S. G. Konda, B. M. Shaikh, S. A. Chavan, B. S. Dawane, Chinese Chemical Letters 22 (2011) 65-68.

H. Schutz, Comprehensive Heterocyclic Chemistry 1 (1984) 116.

K. Roberts, A. Ursini, R. Barnaby, P. G. Cassara, M. Corsi, G. Curotto, D. Donati, A. Feriani, G. Finizia, C. Marchioro, D. Niccolai, B. Oliosi, S. Polinelli, E. Ratti, A. Reggiani, G. Tedesco, M. E. Tranquillini, D. G. Trist, F. T. M. van Amsterdam, Bioorganic & Medicinal Chemistry 19 (2011).

A. Solankee, K. Patel and R. Patel, E-Journal of Chemistry 9 (2012) 1897-(1905).

National Committee for Clinical Laboratory Standards (NCCLS), 940, West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898, USA. Performance Standards for Antimicrobial Susceptibility Testing; Twelfth Informational Supplement (ISBN 1-56238454-6), 2002, M100-S12 (M7).

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