Synthesis of N'-(7-Chloroquinolin-4-yl)-6-Methyl-2-Oxo-4-Phenyl-1,2,3,4-Tetrahydropyrimidine-5-Carbohydrazide Derivatives as Potent Antibacterial Agents

Bhoi, Manoj N.; Borad, Mayuri A.; Pithawala, Edwin A.; Modi, Shweta; Patel, Hitesh D.

doi:10.18052/www.scipress.com/ILCPA.56.82

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Synthesis of N'-(7-Chloroquinolin-4-yl)-6-Methyl-2-Oxo-4-Phenyl-1,2,3,4-Tetrahydropyrimidine-5-Carbohydrazide Derivatives as Potent Antibacterial Agents

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Abstract:

Some novel N'-(7-chloroquinolin-4-yl)-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carbohydrazide derivatives were synthesized via three step reactions by convectional method. The structures of all the compounds have been confirmed by FT-IR, NMR, and MASS and by elemental analysis. We have been evaluated it inhibition capacity for various gram positive and gram negative bacterial strain. All compounds were found to be good to excellent active against all four bacterial strains.

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Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 56)

Pages:

82-90

DOI:

10.18052/www.scipress.com/ILCPA.56.82

Citation:

M. N. Bhoi et al., "Synthesis of N'-(7-Chloroquinolin-4-yl)-6-Methyl-2-Oxo-4-Phenyl-1,2,3,4-Tetrahydropyrimidine-5-Carbohydrazide Derivatives as Potent Antibacterial Agents", International Letters of Chemistry, Physics and Astronomy, Vol. 56, pp. 82-90, 2015

Online since:

Jul 2015

Authors:

Manoj N. Bhoi, Mayuri A. Borad, Edwin A. Pithawala, Shweta Modi, Hitesh D. Patel

Keywords:

Antibacterial Activity, Bacterial Strain, Biginelli Reaction, Dihydropyrimidines, Quinolines

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Open Access

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