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International Letters of Chemistry, Physics and Astronomy
Volume 53
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Synthesis, Spectral Correlations and Antimicrobial Activities of 2-Pyrimidine Schiff’s Bases

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Abstract:

In the present study, a series of substituted (E)-N-benzylidene-2-aminopyrimidine compounds have been synthesized by condensation reaction with 2-aminopyrimidine and meta- and para- substituted benzaldehydes. These synthesized Schiff’s base compounds are confirmed by their physical constants, UV, IR and NMR spectral data. All the observed UV absorption maximum λmax(nm), IR frequencies νC=N(cm-1), NMR δ(ppm) of C-H & C=N chemical shifts have been correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analyses in order to study the effect of substituents on these spectral data has been studied. The antimicrobial activities of all the synthesized Schiff’s base compounds have been studied using Bauer-Kirby disc diffusion method

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Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 53)
Pages:
154-164
Citation:
R. Senbagam et al., "Synthesis, Spectral Correlations and Antimicrobial Activities of 2-Pyrimidine Schiff’s Bases", International Letters of Chemistry, Physics and Astronomy, Vol. 53, pp. 154-164, 2015
Online since:
July 2015
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Cited By:

[1] R. Senbagam, R. Vijayakumar, M. Rajarajan, S. Balaji, V. Manikandan, G. Vanangamudi, G. Thirunarayanan, "Synthesis, assessment of substituent effect and antimicrobial activities of (4E)-4-(benzylideneamino)-1,2-dihydro-2,3-dimethyl-1-phenylpyrazol-5-one compounds", Karbala International Journal of Modern Science, Vol. 2, p. 56, 2016

DOI: https://doi.org/10.1016/j.kijoms.2016.01.004